Nutrient Absorption in Lean Versus Obese Individuals

这项研究检查了两种标准饮食（卡路里含量不同）的肥胖和瘦个体以及粪便和尿液能量损失，以比较瘦个体与肥胖个体的这些值。该研究还调查了粪便中特定的常量营养素含量，以检查瘦和肥胖个体之间这些参数的差异。这些测量的可重复性也在一个个体子集中进行测试。与圣路易斯华盛顿大学的Jeffrey Gordons博士实验室合作，将粪便样本送去测定粪便细菌植物群类型，以检查粪便能量损失与肠道植物群种群之间的关联。 最初的14个瘦的和9个肥胖的个体的初步结果没有显示出粪便或尿液能量损失的任何差异。两组粪便的热量范围很大，从2%到9%不等。每种饮食的粪便卡路里损失与每个个体相关。在高热量饮食中，肥胖个体比瘦个体有更大的粪便热量损失（因此吸收更少的食物）。粪便细菌植物群类型的进一步结果目前正在等待中。

This study examines obese and lean individuals on two standard diets (which differ by calorie content) and the stool and urine energy losses to compare these values in lean versus obese individuals. The study is also investigating the specific macronutrient content of stool to examine differences in these parameters between lean and obese individuals. The repeatability of these measurements is also being tested in a subset of individuals. In collaboration with Dr. Jeffrey Gordons lab at Washington University in St. Louis, samples of stool will be sent for determination of the fecal bacterial flora phylotypes to examine the association between stool energy loss and enteric flora populations. Preliminary results from an initial 14 lean and 9 obese individuals failed to show any difference in stool or urine energy loss. The range of calories stool was large, varying from 2 to 9 % in both groups. Stool calorie loss on each diet was associated in each individual. On the higher calorie diet, obese individuals had greater stool calorie loss (so absorbed less food ) than lean. Further results on fecal bacterial flora phylotypes are currently pending.