UCSD Rodent Phenotyping Core

描述(申请人提供)：基于动物的研究的持续增长导致加州大学圣迭戈分校的老鼠数量在过去十年中增加了两倍。最近建立了啮齿动物表型鉴定核心设施，为加州大学圣地亚哥分校正在研究的一系列关键生物医学问题的啮齿动物调查提供表型分析。提供关键的表型鉴定设备，以分析每天存在的45000多箱啮齿动物中的任何一种，是建立这一核心资源的基础。由此产生的对昂贵的重复空间和资源的需求的减少也是加州大学圣迭戈分校动物研究计划可持续发展计划的关键组成部分。需要资金购买涵盖新陈代谢、学习、记忆、感觉运动、听觉和神经学功能的9个关键表型系统，这些系统将为从神经退化到内分泌到遗传障碍的各种研究提供新的或最新的能力。我们的具体目标是1)扩大集中式啮齿动物表型鉴定计划，使关键测试适用于所有UCSD PHS资助的研究人员，以及2)使UCSD PHS资助的研究人员的集中式啮齿动物核心表型鉴定能力现代化。由于这一核心设施的成功运行要求已经制定，包括空间、技术专长、各种试验方案的相关住房以及支持行政管理的在线信息处理系统，包括从其他设施转移动物，所需设备将立即对迫切需要相关表型分析的研究产生影响。

DESCRIPTION (provided by applicant): Continual growth in animal based research has led to a tripling of the UCSD mouse population over the past decade. The Rodent Phenotyping Core facility was recently established to provide phenotypic analysis for rodent-based investigations into a wide array of critical biomedical issues under study at the University of California, San Diego. Making key phenotyping equipment available for analysis of any of the over 45,000 boxes of rodents present on a daily basis was the basis for the establishment of this core resource. The resultant decreased need for costly duplication of space and resources is also a key component to the sustainability plan for the UCSD animal research program. Funding is requested to purchase nine key phenotyping systems encompassing metabolism, learning, memory, sensorimotor, auditory and neurologic functions that will offer new or updated capabilities for the studies ranging from neurodegenerative to endocrine to genetic disorders. Our specific aims are to 1) expand the centralized rodent phenotyping program making key testing available to all UCSD PHS funded researchers, and 2) modernize centralized rodent core phenotyping capabilities for UCSD PHS funded researchers. Because successful operating requirements for this core facility have been worked out including, space, technical expertise, associated housing for variable testing regimens, and online information handling system to support administration including transfer of animals from other facilities, the requested equipment will have an immediate impact on studies with the critical need for associated phenotypic analysis.