American Society for Intercellular Communication (ASIC)

翻译后摘要：目前的R13的建议是从美国社会细胞间通信（ASIC） 该研究所成立于2021年1月，目标是为包括新兴市场在内的研究创造一个家园。 介质和途径的细胞间通讯（IC）超出了现有的社会范围。 组织者专注于定期的年度会议，对细胞外囊泡，生物分子 缩合物和RNA（EV/EP/ExRNA）等复杂的分子交换途径。第2 会议（2022年10月13日至15日）有149名与会者，95%亲自出席。我们从一个“前- NCATS，NIDDK，NIC和NHLBI项目官员及其资助的PI的会谈。 诺贝尔奖得主托马斯·苏德霍夫博士是我们星期四晚上开幕式的主旨发言人。 2023年的会议将为对基础科学感兴趣的年轻科学家提供一个知识之家。 科学和实验室床旁相关EV和非EV类型的研究。会议地点 （Bolger Center; Potomac，MD）提供了一个平台，允许PI之间直接通信， 来自对EV研究感兴趣的政府机构的项目官员，包括NIH、NIST、FDA和 NSF。会议在许多方面都是独特和新颖的，包括涵盖广泛的IC主题 这些过程远远超出了现有社会的关注范围，这些社会在很大程度上由外来体主导， 相关研究。此外，会议的成本很低，所以学生，博士后和PI可以负担得起 参加;建议召开会前研讨会，以便与来自不同领域的参与组织直接接触 NIH资助机构;会议将增加DEI库，重点是妇女和少数民族 学员;包括辅导会议（速配）将促进创造导师的相声- 学员对，这将有助于年轻的学员;和赠款写作讲习班是独一无二的，因为它讨论 如何编写各种类型的EV和非EV赠款（即，NIH的K、R、T、P和U系列）， 经验丰富的调查员我们2023年会议的目标包括：汇集来自不同领域的研究人员 基础科学和临床领域，讨论和促进对多因素影响的理解， EV/EP/ExRNA在诊断，治疗和正常与非正常的生物起源的基本理解。 疾病状态（AIM 1）;吸引年轻的新研究人员（包括妇女和少数民族）参与该领域 EV/EP/ExRNA和他们的进步，成为独立的成功的同事， 他们写更好的赠款（AIM 2）;并召集有关各方讨论相关的关键重要 关于IC的主题，并向科学界传播会议上提出的信息- 以及卫生保健提供者和公众。这也将有助于找到合格的 NIH研究部分的评审员（AIM 3）。

Abstract: The current R13 proposal is from the American Society for Intercellular Communication (ASIC) which was created in January 2021 with a goal of creating a home for research encompassing emerging mediators and pathways of intercellular communication (IC) beyond the scope of the existing societies. Organizers have focused on regular yearly meetings with interest in extracellular vesicles, Biomolecular Condensates and RNA (EV/EP/ExRNA) and other complex pathways of molecular exchange. The 2nd meeting (October 13th- 15th, 2022) had 149 participants, 95% attended in-person. We started with a “Pre- meeting” session with talks from NCATS, NIDDK, NIC, and NHLBI program officers and their funded PIs. Nobel Laurette Dr. Thomas Sudhof was our keynote speaker for the opening Thursday night session. The 2023 current meeting will provide an intellectual home for young scientists who are interested in basic science and bench to bedside related EV and non-EV type of research. The location of the meeting (Bolger Center; Potomac, MD) provides a platform that allows direct communication between PIs and program officers from government agencies with interest in EV research including NIH, NIST, FDA, and NSF. The meeting is unique and novel in many ways including topics covering a broad range of IC processes far beyond the focus of existing societies that have largely been dominated by exosome- related research. Also, the cost of the meeting is low, so that students, postdocs, and PIs can afford to attend; there is a proposed pre-meeting workshop which allows direct contact with POs from various NIH funding agencies; the meeting will increase the DEI pool with emphasis on women and minority trainees; inclusion of a mentoring session (speed dating) will promote a cross talk for creating mentor- mentee pairs, that will help young trainees; and a grant writing workshop is unique in that it discusses how to write various types of EV and non-EV grants (i.e., K, R, T, P and U series for NIH) for early and seasoned investigators. Our Aims for the 2023 meeting include: Bring together investigators from diverse basic science and clinical fields to discuss and advance understanding of the multifactorial impact of EV/EP/ExRNA in diagnostics, treatments, and a basic understanding of the biogenesis of normal vs. diseases states (AIM 1); Engage young new investigators (including women and minorities) in the field of EV/EP/ExRNA and their advancement in becoming independent successful colleagues by helping them write better grants (AIM 2); and Bring together interested parties to discuss relevant key significant topics regarding IC, and disseminate information presented at the conference to the scientific community- at-large as well as to health care providers and the general public. This would also help in finding qualified reviewers for NIH study sections (AIM 3).