The Helicase and Nucleic Acid-based Machines Conference: Structure, Mechanism, Regulation and Roles in Human Diseases

项目总结/摘要 这项申请的目标是获得资金，以支持两年一度的FASEB会议 解旋酶和核酸机器：结构、机制、调节和作用 人类疾病，2023年7月16日至20日，在南桥，MA。这将是第14次会议， 会议FASEB的使命是“通过促进研究来促进健康和福祉 通过合作宣传和服务促进生物和生物医学科学的发展和教育 对我们的成员协会及其成员”。2023年会议将重点关注以下人员的角色 DNA和RNA解旋酶，定义基因表达的基本过程，基因组 完整性和病毒复制。为我们的与会者计划了两个培训课程：一个是“会见- 专家”会议，其中将包括一系列的主题，从开始自己的实验室，以工作生活 平衡和多样性，公平和包容性（DEI）主题演讲，将定位于 在晚餐时，最大的出席。所要求的资金将用于有限的旅行， 邀请演讲者和学生和博士后，初级教师旅行奖，我们邀请DEI 扬声器.九个专题会议安排，从翻译后基因 调节DNA损伤和修复，所有这些都与人类疾病密切相关。 这对于癌症子集尤其如此，如DNA损伤，修复效率低下或不完全， 异常基因表达是众所周知的标志。

Project Summary/Abstract The goal of this application is to obtain funding to support the biennial FASEB conference Helicases and Nucleic Acid-Based Machines: Structure, mechanism, regulation, and roles in human diseases, July 16-20, 2023, in Southbridge, MA. This will be the 14th meeting of this conference. The FASEB mission is to “advance health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to our member societies and their members”. The 2023 conference will focus on the roles of DNA and RNA helicases, which define fundamental processes of gene expression, genome integrity, and viral replication. Two training sessions are planned for our attendees: one “Meet- the-Experts” session, which will include a range of topics from starting your own lab to work-life balance and a diversity, equity, and inclusion (DEI) keynote address that will be positioned during dinner for maximum attendance. The requested funds will support limited travel for invited speakers and travel awards for students and postdocs, junior faculty, and our invited DEI speaker. Nine topical sessions are scheduled which range from post-translational gene regulation to DNA damage and repair, all of which are intimately connected to human diseases. This is especially true for cancer subsets as DNA damage, inefficient or incomplete repair, and aberrant gene expression are well known hallmarks.