Building Capacity in Evidence-based HIV Prevention Research for MSM in China

描述（由申请人提供）：我们建议加强我们在中国男男性行为者（MSM）中开发、实施和评估数据和理论驱动的艾滋病预防干预措施的能力。2005年，中国估计有65万人感染艾滋病毒，并且传播正在从注射吸毒者转移到通过性传播的高危人群。尤其是男男性接触者，现在艾滋病毒的流行率可能正在迅速上升。在北京，艾滋病毒流行率从2004年的不到1%上升到2006年的5%以上。据统计，重庆男男性行为者的艾滋病毒感染率已超过15%。虽然基层社区和国家支持的MSM预防项目正在激增，但它们通常没有严格的流行病学数据或基于理论的预防方法的指导。我们提出了一个为期四年的计划，逐步完善中国男同性恋者艾滋病流行病学调查、预防规划和干预研究的理论基础。我们的工作背景将是三个连续的横断面受访者驱动抽样（RDS）调查，辅以行为研究的具体培训，形成性研究以适应和验证中国的详细行为工具，并评估北京和重庆现有的MSM预防项目的覆盖范围和影响。除了增强我们开展未来大规模艾滋病毒预防干预措施的随机对照试验的能力外，通过本提案收集的数据将立即应用于针对导致我国MSM中艾滋病毒传播的因素和行为。凭借我们团队在本地和国际资助的MSM项目中的领导地位，我们准备迅速将研究结果纳入正在进行的努力中。公共卫生相关性：作为第一个在男男性行为者中进行的研究之一，该项目将有助于了解艾滋病在中国这一人群中的流行情况。它还将有助于识别高风险群体，开发合适的调查工具来调查男男性行为的风险行为，以及评估研究领域正在进行的项目的有效性。

DESCRIPTION (provided by applicant): We propose to strengthen our capacity to develop, implement, and evaluate data- and theory- driven HIV prevention interventions among men who have sex with men (MSM) in China. An estimated 650,000 persons were living with HIV in China in 2005 and transmission is shifting from injection drug users to populations at risk through sexual transmission. MSM in particular may be experiencing a rapid rise in HIV prevalence right now. In Beijing, HIV prevalence rose from less that 1% in 2004 to over 5% in 2006. HIV prevalence among MSM in Chongqing has already been measured over 15%. While grassroots community- and state- supported prevention programs for MSM are proliferating, they generally have not been guided by rigorous epidemiological data or by theory-based prevention approaches. We propose a four year program to progressively improve the theoretical foundation for HIV epidemiological surveys, prevention programs, and intervention research for MSM in China. The context of our effort will be three serial cross-sectional respondent-driven sampling (RDS) surveys, enhanced with specific training in behavioral research, formative research to adapt and validate detailed behavioral instruments for China, and assessment of the coverage and impact of existing prevention programs for MSM in Beijing and Chongqing. In addition to enhancing our capacity to conduct future large scale randomized controlled trials of HIV prevention interventions, the data collected through this proposal will have immediate applications in targeting the factors and behaviors driving HIV transmission among MSM in our country. By virtue of our team's leadership of locally and internationally funded programs for MSM, we are poised to rapidly incorporate findings into on-going efforts. PUBLIC HEALTH RELEVANCE: As one of the first study conducted among men who have sex with men, the project will help understand HIV/AIDS epidemic among this population in China. It will also help identify high risk group, develop suitable survey tool to investigate risk behavior of men who have sex with men, as well as evaluate the effectiveness of ongoing programs in study areas.