Core Support for Cancer Center

描述(由申请人提供)：这是爱因斯坦癌症中心35年的续期CCSG资金申请，该中心在1972年获得了第一个NCI称号。有七个既定的项目。这些学科包括：免疫肿瘤学(Scharff)、肿瘤微环境和转移(Condeelis)、细胞生长和分化控制(Skoultchi)、分子膜生物学(Stanley)、实验治疗学(Horwitz)、癌症流行病学(Rohan)和结肠癌生物学(Augenlicht)。AECC项目的癌症重点得到加强，反映在NCI的拨款从2000年的74笔增加到2006年的95笔，目前向AECC成员提供的NCI支持(直接)为1940万美元。有两个新的由NCI资助的计划赠款：一个是关于动力和侵袭的NCI计划项目赠款，另一个是关于肠癌营养-遗传相互作用的U54中心赠款。AECC已经招募了43名新成员，其中30人是爱因斯坦的新成员。临床肿瘤学领导职位已经有了重大招聘，包括内科肿瘤学(Perez-Soler)、儿科血液/肿瘤学(Gorlick)和放射肿瘤学(Kalicki)的新主席。AECC现在有121个成员。外部科学咨询委员会每年召开一次会议，由11名成员组成。有9个已建立的共享资源，包括蛋白质组学、结构生物学(X射线、同步加速器、核磁共振)、流式细胞仪、分析成像、组织病理学、转基因、动物屏障、基因靶向和基因组学(DNA测序+微阵列服务)。自上次审查以来，生物统计共享资源是通过CCSG的一项补充提供资金的，并包括在本申请中。需要资金的新的共享资源包括生物信息学、基因组成像(FISH/Sky)和流行病学信息学。一个新的研究机构，迈克尔·F·普莱斯转化和遗传医学中心将于2007年12月开放，将为动物屏障、转基因、组织病理学和基因靶向共享资源提供20,000平方英尺的资金。大量新招募的AECC人员将被安置在这个设施中。除此之外，还计划通过继续招募癌症流行病学项目和招募行为/预防科学家来扩大人口科学。

DESCRIPTION (provided by applicant): This is an application for renewed CCSG funding for year 35 of the Albert Einstein Cancer Center which received its first NCI designation in 1972. There are seven established programs. These include: Immunooncology (Scharff), Tumor Microenvironment and Metastasis (Condeelis), Cell Growth and Differentiation control (Skoultchi), Molecular Membrane Biology (Stanley), Experimental Therapeutics (Horwitz), Cancer Epidemiology (Rohan) and the Biology of Colon Cancer (Augenlicht). The enhanced cancer focus of AECC programs is reflected in an increase in NCI grants from 74 in 2000 to 95 in 2006 with NCI support to AECC members currently at $19.4M (direct). There are two new NCI-funded programmatic grants: an NCI program project grant on Motility and Invasion and a U54 Center grant on Nutritional-Genetic Interactions in Intestinal Cancer. There has been recruitment of 43 new AECC members of whom 30 are new to Einstein. There have been major recruitments to clinical oncology leadership positions including new chairs of Medical Oncology (Perez-Soler), Pediatric Hematology/Oncology (Gorlick) and Radiation Oncology (Kalnicki). There are now 121 AECC members. The External Scientific Advisory Committee has convened yearly and consists of eleven members. There are nine established shared resources including Proteomics, Structural Biology (X-ray, Synchrotron, NMR), FACS, Analytical Imaging, Histopathology, Transgenic, Animal Barrier, Gene Targeting, and Genomics (DNA sequencing + microarray services). A Biostatistics Shared Resource was funded through a supplement to the CCSG since the last review and is included in this application. New shared resources for which funding is requested include Bioinformatics, Genome Imaging (FISH/SKY), and Epidemiology Informatics. A new research facility, the Michael F. Price Center for Translational and Genetic Medicine will open December 2007 and will provide 20,000 ft2 for the Animal Barrier, Transgenic, Histopathology, and Gene Targeting Shared Resources. A substantial number of new AECC recruits will be housed in this facility. Beyond this, there are plans to expand population sciences through continued recruitment to the Cancer Epidemiology program and recruitment of behavioral/prevention scientists.