课题基金 / 基金详情

SPRINT

SPRINT
短跑
批准号：
7980633
负责人：
Suzanne Oparil
金额：
$67.01万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-09-14 至 2018-09-13
来源：
https://reporter.nih.gov/project-details/7980633
关键词：
SPRINT

项目摘要

项目成果

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中文摘要
翻译
收缩压干预试验(Sprint)承包商将进行一项多中心随机临床试验，以确定将收缩压治疗到比目前推荐的目标更低是否会减少心血管疾病。临床中心网络(CCNS)将提供领导并监督纳入SPRINT CCN中枢和降低高血压(Mind)中的记忆和认知(Mind)子研究的临床站点。Sprint-Mind的目标应包括但不限于：(1)认知功能，以确定SBP低于当前推荐目标的治疗是否会减少认知衰退的发生率和可能的痴呆症的发生率；(2)成像，以确定SBP低于当前建议的目标治疗是否将降低与血管性痴呆症相关的中枢神经系统结构性异常的发生率，以及总脑容量的下降速度；以及(3)可能痴呆症的诊断，以每年对所有短跑参与者进行可能的痴呆症筛查。
英文摘要
The Systolic Blood Pressure Intervention Trial, (SPRINT) contractor will conduct a multicenter, randomized clinical trial to determine whether treating systolic blood pressure to a lower goal than currently recommended, will reduce cardiovascular disease. The Clinical Center Networks (CCNs) shall provide leadership and oversee the clinical sites for inclusion of the SPRINT CCN hub and the Memory and Cognition in Decreased Hypertension (MIND) substudy. The objectives of SPRINT-MIND shall include, but are not limited to: (1) Cognitive functioning to determine whether treating to a SBP lower goal than currently recommended will reduce the incidence of cognitive decline and incidence of probable dementia; (2) Imaging, to determine whether treating to a SBP lower goal than currently recommended will reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume; and (3) Diagnosis of probable dementia, to screen all SPRINT participants annually for probable dementia.
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会议论文
30th Annual Vascular Biology and Hypertension Symposium
Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension (CHAP Maternal Follow-up Study)
Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension (CHAP Maternal Follow-up Study)
Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension (CHAP Maternal Follow-up Study)
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