Laboratory Testing Services

寻找抗癌和艾滋病活性物质的一部分涉及体内试验。国家癌症研究所(NCI)维持着动物生产计划，以提供活体测试所需的必要实验室动物。大部分测试是在近亲繁殖的实验室动物中进行的，例如由动物生产计划合同群体生产的动物。因此，遗传监测合同被用来确定动物生产计划近亲繁殖啮齿动物群体的遗传纯度。确认和核实NCI动物生产计划的遗传状态是这项工作的主要目标。这项工作是通过利用基于DNA的方法来确定遗传纯度以及生物化学标记和皮肤移植的备份方法来完成的。

A part of the search for active agents against Cancer and AIDS involves in vivo testing. The National Cancer Institute (NCI) maintains the Animal Production Program to supply the necessary laboratory animals needed for this in vivo testing. Much of the testing is performed in inbred laboratory animals such as the ones produced by the Animal Production Program contract colonies. Thus, a genetic monitoring contract is used to determine the genetic purity of the Animal Production Program inbred rodent colonies. The validation and verification of the genetic status of the NCI Animal Production Program is the primary objective of this effort. This effort is accomplished by utilizing DNA-based methods to determine genetic purity along with backup methods of biochemical markers and skin grafts.