Synthesis and Study of Complex Natural Products

描述（由申请人提供）：研究复杂天然产物的基本化学和生物活性是了解其作用机制和开发疾病治疗方法的关键。本研究项目旨在通过有机合成新策略和新方法的应用和发展，开发结构复杂、化学复杂和具有生物活性的天然产物的高效合成。受生物遗传学因素启发的策略被追求为化合物家族提供潜在的更广泛的解决方案，同时提供对可能的生物合成途径负责其生物发生的见解。靶点的选择是基于有趣的和新颖的分子结构，先前合成研究的缺乏，生物活性以及未来化学和生物机制研究的潜力。

DESCRIPTION (provided by applicant): The study of the fundamental chemical and biological activity of complex natural products is key to understanding their mechanism of action and developing therapeutics for the treatment of diseases. This research program aims to develop efficient synthesis of structurally complex, chemically intricate and biologically active natural products through the application and development of new strategies and methodologies for organic synthesis. Strategies inspired by biogenetic considerations are pursued to afford potentially broader solutions to families of compounds while providing insight into the possible biosynthetic paths responsible for their biogenesis. Targets are selected on the basis of interesting and novel molecular architecture, paucity of prior synthetic studies, biological activity, and the potential for future chemical and biological mechanistic studies. The planned syntheses are designed to develop new complexity generating sequence of reactions, in particular multiple carbon-carbon bond forming cascades and to challenge existing synthetic methods in addition to inspire the development of new and efficient methodologies for the synthesis of complex molecules.