A Quality Assurance, Coordination and Analysis Center for HMP

人类物种的生存依赖于数十亿微生物的活动， 人体内和人体上的多个环境小生境。人类微生物组计划（Human Microbiome Project，HMP） NIH Roadmap计划旨在收集有关人类复杂性的前所未有的大量数据 微生物群落数据将由多个HMP测序中心生成。以确保 为了使数据发挥最大的作用，将成立一个数据分析和协调中心（DACC）。这一任务 通过五个研究小组之间的多机构合作完成， 互动，并在与此项目相关的一系列学科的丰富经验。领导人 五个小组是：（i）Owen白色，基因组科学研究所，马里兰州医学院， 巴尔的摩，马里兰州;（ii）维克托马科维茨，劳伦斯伯克利国家实验室，伯克利，加利福尼亚州;（iii）尼科斯Kyrpides， 美国能源部联合基因组研究所（JGI）核桃溪，加利福尼亚州;（iv）罗布奈特，化学和生物医学系 生物化学，科罗拉多大学，博尔德CO;（v）加里安德森，劳伦斯伯克利国家 实验室，加利福尼亚州伯克利。DACC的建设将通过以下四个具体目标来实现： 1.创建人类微生物组数据存储（HMDS），其中将包含从HMP收集的所有数据 通过标准化格式、受控词汇、人类微生物组项目 目录（HMPC）跟踪系统，并链接到标准操作程序（SOP）。2.发展 一个综合计算分析管道，它将包括一个初始的核心元素集， 随着对宏基因组分析有用的新工具的开发， 或其他地方。3.开发数据集成与分析系统（DAIS）以支持基于Web的 分析和将采用大量的数据减少和集成系统以及numerouse数据 勘探工具将基于类似的现有资源，如IMG和IMG/M中发现的资源。4. 通过对目标用户群体的调查、在相关地点举办讲习班， 会议、现场培训课程以及在线教程和研讨会。

The human species is dependent for its survival upon the activities of billions of microorganisms that inhabit multiple environmental niches within and on the human body. The Human Microbiome Project (HMP) is an NIH Roadmap program designed to collect unprecedented amounts of data about the complexity of human microbial communities. The data will be generated by multiple HMP sequencing centers. To ensure that the data is maximally useful, a Data Analysis and Coordination Center (DACC) will be formed. This task will be accomplished via a multi-instiutional collaboration between five research groups with a history of close interactions, and extensive experience in a range of disciplines relevant to this project. The leaders of the five groups are: (i) Owen White, Institute for Genome Sciences, Univeristy of Maryland School of Medicine, Baltimore, MD; (ii) Victor Markowitz, Lawrence Berkeley National Lab, Berkely, CA; (iii) Nikos Kyrpides, DOE-Joint Genome Institute (JGI) Walnut Creek, CA; (iv) Rob Knight, Department of Chemistry and Biochemistry, University of Colorado, Boulder CO; (v) Gary Anderson, Lawrence Berkeley National Laboratory, Berkeley, CA. Construction of the DACC will be accomplished through these four specific aims: 1. Creation of a Human Microbiome Data Store (HMDS) which will contain all data collected from the HMP centers organized through standardized formats, controlled vocabularies, a Human Microbiome Project Catalog (HMPC) tracking system, and links to Standard Operating Procedures (SOPs). 2. Development of a Comprehensive Computational Analysis Pipeline which will consist of an initial core set of elements and will be expanded over time as new tools useful to metagenomic anlaysis are developed either at the DACC or elsewhere. 3. Development of a Data Integration and Analysis System (DAIS) to support Web-Based Analysis and which will employ numerous data reduction and integration systems as well as numerouse data exploration tools that will be based on similar existing resources such as those found in IMG and IMG/M. 4. Engage in community outreach and training via surveys of target user groups, workshops at relevant conferences, onsite training courses, and online tutorials and seminars.