Pathology Support for NTP Quality Assessment

该合同的目的是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。由国家毒理学计划（NTP）进行的病理学同行评审已成为确保啮齿动物生物测定中生成的病理学数据有效性的标准方法。NTP在这方面的主要工作包含在病理质量评估合同中[NTP质量评估（QA）的病理支持]。根据该合同，病理材料（载玻片、块等）评价质量（染色等）和完整性（载玻片、组织块匹配、存在组织等）。此外，大多数内部研究和在与NTP签订合同的实验室中进行的所有NTP研究的病理学诊断均由第二名病理学家进行验证。目前，病理学表格以电子方式接收并格式化，供QA病理学家使用。研究病理学家和QA病理学家之间的所有差异均在QA叙述中突出显示，该叙述与切片一起提交给NTP。由病理学工作组（PWG）主席评价差异，PWG主席负责选择代表性病例进行PWG审查。QA病理学家和其他专家参与PWG同行评审，在不了解研究或QA病理学家诊断的情况下检查选定病例。 病理学质量评估;病理学质量保证;病理学;病理学同行评议;国家毒理学计划;啮齿动物生物测定; NTP; PWG;病理学家;兽医病理学;技术报告;亚慢性;慢性; 90天; 2年;质量保证

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Pathology peer review as carried out by the National Toxicology Program (NTP) has become a standard means of assuring the validity of the pathology data generated in the rodent bioassays. A major portion of the NTP effort in this regard is contained in the contract for pathology quality assessment [Pathology support for the NTP-Quality Assessment (QA)]. Under this contract, pathology materials (slides, blocks, etc.) are evaluated for quality (staining, etc.) and integrity (slide, block match, presence of tissues, etc.). Also, the pathology diagnosis for most in-house studies and all NTP studies carried out in the laboratories under contract to the NTP are verified by a second pathologist. Currently, the pathology tables are received electronically and formatted for use by the QA pathologists. All discrepancies between the study pathologist and the QA pathologists are highlighted in a QA narrative which is submitted together with the slides to the NTP. The discrepancies are evaluated by the Pathology Working Group (PWG) chairperson who is responsible for selecting representative cases for PWG review. The QA Pathologist and other experts participate in the PWG Peer Review where selected cases are examined without knowing either the study or QA Patholgist's diagnosis. Keywords pathology quality assessment; pathology QA; pathology; pathology peer review; national toxicology program; rodent bioassay; NTP; PWG; pathologist; veterinary pathology; technical reports; subchronic; chronic; 90-day; 2-year; QA