Identification of effectors of host cell killing by Entamoeba histolytica

描述（由申请人提供）：从这项工作中，我们期望鉴定细胞毒性效应物，并测试它们是否需要被运输到宿主细胞中以发挥其凋亡作用。这些研究的成功完成将阐明疾病发病机制的基本机制，这将为正在进行的E。溶组织疫苗和新的治疗方法，并可能揭示菌株特异性差异的阿米巴毒力。由于感染在发展中国家的儿童中很常见，并且是发病率和死亡率的重要原因，这些研究有望对全球儿童健康产生积极影响。

DESCRIPTION (provided by applicant): From this work, we expect to identify the effectors of cytotoxicity and to test if they need to be trafficked into host cells to exert their apoptotic effect. Successful completion of these studies will clarify the basic mechanisms of disease pathogenesis which will inform ongoing efforts in the development of an E. histolytica vaccine and new therapeutics and may shed light on strain-specific differences in amebic virulence. Since infection is common in children in the developing world and is a significant cause of morbidity and mortality, these studies have promise to positively impact global child health.