Faculty Recruit for Washington University Diabetic Cardiovascular Disease Center

描述（由申请人提供）：本申请通过NIH P30机制（OD-09-005）向国家心肺血液研究所（NHLBI）寻求资源支持，为华盛顿大学糖尿病心血管疾病中心（DCDC）招募一名新的独立助理教授。DCDC是一个最近成立的跨学科研究中心，汇集了来自不同领域的科学家，以促进我们对导致糖尿病患者心肌和血管疾病过度负担的机制的理解，并迅速将新发现转化为诊断工具和治疗方法的发展。在DCDC的支持下，跨学科的科学家团队正在探索葡萄糖和脂质代谢紊乱与糖尿病性心脏病之间的相互作用。正在进行的项目的目标之一是开发新的血液和成像生物标志物。我们建议招募的杰出人士Jeffrey Henderson，医学博士，将为中心带来炎症，感染和动脉粥样硬化之间交叉的新焦点。亨德森博士在使用灵敏的质谱技术鉴定尿液生物标志物方面也有独特的专业知识。P30的资源，结合医学部和DCDC提供的资源，以及本文所述的全面指导和职业发展计划，将为这位在与NHLBI高度相关的领域受过良好训练且非常有前途的个人未来的成功奠定基础。

DESCRIPTION (provided by applicant): This application seeks support from the National Heart, Lung & Blood Institute (NHLBI) through the NIH P30 mechanism (OD-09-005) for resources to recruit a newly independent assistant professor to the Diabetic Cardiovascular Disease Center (DCDC) at Washington University. DCDC is a recently established interdisciplinary research center that brings together scientists from diverse fields in work to advance our understanding of the mechanisms that contribute to the excess burden of myocardial and vascular disease in diabetics, and to rapidly translate new findings into development of diagnostic tools and therapeutic approaches. Under the auspices of DCDC, interdisciplinary teams of scientists are exploring the interactions between derangements in glucose and lipid metabolism and diabetic cardiac disease. One of the goals of ongoing projects is the development of new blood-based and imaging biomarkers. The outstanding individual we propose to recruit, Jeffrey Henderson, MD, PhD, will bring a new focus to the Center at the intersection between inflammation, infection and atherosclerosis. Dr. Henderson also has unique expertise in the use of sensitive mass spectrometry techniques for identification of urinary biomarkers. The resources of the P30, combined with the resources being provided by the Department of Medicine and DCDC and the thorough mentoring and career development plan described herein, will set the stage for the future success of this well-trained and highly promising individual in an area of high relevance to NHLBI. Diabetes is associated with serious cardiovascular complications including aggressive atherosclerosis and heart failure that is unrelated to atherosclerosis. The goal of the Diabetic Cardiovascular Disease Center is to develop new biomarkers for more effective diagnosis and treatment of this cardiovascular disease. This P30 program will support the recruitment to the Center of a well trained, promising young scientist.