The Neurobiology of Self Appraisals and Social Cognition in Depressed Adolescents

描述（由申请人提供）：拟议研究的目标是研究自我和社会认知方面的神经基础-消极的自我评价和对消极情绪社会信号的高度关注-这与了解青少年抑郁症的发展高度相关。持续的负面自我评价和对负面情绪社会信号（例如负面面部表情）的高度关注是表示一生中抑郁症风险的关键过程。这些过程与理解青春期抑郁症的风险特别相关，因为这是一个自我评价和人际社会功能快速转变的时期，这是形成积极和连贯的自我表征的关键发展任务的一部分。这种发展任务的次优解决方案与抑郁症的发作和复发以及青春期自杀的风险有关。因此，了解青少年抑郁症中消极自我评价的神经基础和对消极面部表情的关注，将为了解这一脆弱发展时期抑郁症的具体神经机制提供有价值的见解，以指导干预策略。此外，这项研究还将有助于确定青少年抑郁症的客观神经生物学标志物，这些标志物可用于未来检测那些可能最有可能患上未来抑郁症的青少年或处于疾病复发过程中的青少年。 公共心理健康的一个关键目标是确定青少年患有慢性终身抑郁症的高风险。目前的建议的目的是检查模式的异常脑功能参与消极的自我和社会认知抑郁症的青少年。识别这些异常脑功能的模式可以用来检测抑郁的青少年谁是在慢性终身抑郁症的高风险，以告知新的预防和治疗策略。

DESCRIPTION (provided by applicant): The goal of the proposed study is to study the neural basis of aspects of self and social cognition - negative self appraisals and elevated attention to negative emotional social signals - that are highly relevant to understanding the development of adolescent depressive disorders. Persistently negative self appraisal and elevated attention to negative emotional social signals, (e.g. negative facial expressions) are key processes that denote risk for depressive disorders across the lifespan. These processes are particularly relevant to understanding risk for depression in adolescence, because this is a period during which there is rapid transformation in self appraisals and interpersonal social functioning as part of the key developmental task of forming a positive and coherent self representation. Suboptimal resolution of this developmental task is linked to onset and recurrence of depressive disorders and risks for suicide in adolescence. Therefore, understanding the neural basis of negative self appraisals and attention to negative facial expressions in adolescent depression will provide valuable insights into specific neural mechanisms of depression during this vulnerable developmental period to guide intervention strategies. Furthermore, this research will also help identify objective, neurobiological markers of adolescent depressive disorders that can be used in the future to detect those adolescents who may be most at risk of future depression or who are on a trajectory to a recurrent course of the illness. PUBLIC HEALTH RELEVANCE: A critical goal of public mental health is to identify adolescents that are at high risk for chronic lifetime depression. The aim of the current proposal is to examine patterns of abnormal brain function involved in negative self and social cognition in depressed adolescents. Identifying these patterns of abnormal brain function could be used to detect depressed adolescents who are at heightened risk for chronic lifetime depression in order to inform new prevention and treatment strategies.