Aspen Perinatal Biology Conference

描述(申请人提供)：本申请申请资助2010年8月28日至31日举行的Aspen围产期生物学会议。该会议每3年组织一次，讨论与宫内应激及其对胎盘发育和胎儿结局的影响有关的主题。它的重点是确定围产期机制，将怀孕期间的孕产妇疾病与胎儿适应联系起来，并对了解孕产妇/胎儿健康和胎儿规划对后代的长期后果具有广泛影响。生长受限的胎儿出生时患高血压、糖尿病和肥胖症的风险增加。最近的研究已经确定，营养改变(包括喂养不足和过度喂养的母亲)、缺氧、妊娠期糖尿病、先兆子痫和药物暴露是宫内应激源，这些应激源会改变特定的细胞机制，导致胎儿的直接后果和通过胎儿编程进入成年的持久影响。由于围产期医学是一个多学科的领域，这次会议的目标是将基础科学家和围产科医生聚集在一起，讨论导致正常和异常胎儿结局的母体、胎盘和胎儿机制。拟举行的为期2.5天的会议分为3次全会幻灯片会议、1次主旨演讲、2次海报会议和2次研讨会讲座。会议的4个具体目标是：1)了解与孕期母体适应有关的细胞机制，2)讨论目前在胎盘功能和胎儿成熟中重要的机制，3)了解不利的宫内环境对胎儿发育的相互作用，以及4)确定有助于胎盘/胎儿适应不良妊娠条件的关键因素。三次全体会议将包括以下主题：1)导致宫内压力的母体状况，2)营养物质运输/内分泌产生的胎盘机制，以及3)胎儿适应机制。演讲者将包括1)在孕期母体、胎盘和胎儿适应机制领域建立良好基础的高级研究人员，2)开始在生殖医学领域建立成功职业生涯的年轻研究人员，以及3)博士后和研究生。海报会议将为年轻研究人员提供与与会者直接互动的形式。重点讲座将是“胎盘血管发生的机制”，这将引起围产期生物学领域的广泛兴趣。研讨会讲座将讨论“胎盘成像技术”和“表观遗传机制的分子调控”。这次基础科学家和临床医生会议的广泛兴趣在于了解不良妊娠结局的潜在机制，预计将就如何解决宫内应激在肥胖、糖尿病和心血管疾病等全球健康问题中的影响产生新的想法。 公共卫生相关性：本申请申请资助2010年8月28日至31日举行的Aspen围产期生物学会议。这将是一个3D会议，包括3个全会幻灯片会议、1个主旨讲座、2个海报会议和2个研讨会讲座。由于围产期医学是一个多学科的领域，这次会议的目标是将基础科学家和围产科医生聚集在一起，讨论紧张的宫内环境对导致胎儿结局改变的母体、胎盘和胎儿机制的影响。

DESCRIPTION (provided by applicant): This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This Conference is organized every 3 years to encompass topics related to intrauterine stress and its impact on placental development and fetal outcomes. Its focus is to identify perinatal mechanisms that link maternal illnesses during pregnancy and fetal adaptations and has broad implication for understanding maternal/fetal health and the long term consequences of fetal programming on the offspring. Growth restricted fetuses are born with an increased risk of hypertension, diabetes, and obesity. Recent studies have now identified altered nutrition (both the under- and overfed mother), hypoxia, gestational diabetes, preeclampsia, and drug exposure as intrauterine stressors that alter specific cellular mechanisms leading to both immediate consequences in the fetus and lasting effects into adulthood through fetal programming. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the maternal, placental and fetal mechanisms that contribute to both normal and altered fetal outcomes. The proposed 2.5 day conference is organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. The 4 specific goals of the conference are: 1) to understand the cellular mechanisms associated with maternal adaptations during pregnancy, 2) to discuss the current mechanisms important in placental function and fetal maturation, 3) to understand the interaction of adverse intrauterine environments on fetal development, and 4) to identify key factors important in contributing to placental/fetal adaptations to adverse pregnancy conditions. The 3 Plenary Sessions will include topics on 1) Maternal Conditions Causing Intrauterine Stress, 2) Placental Mechanisms of Nutrient Transport/Endocrine Production, and 3) Fetal Adaptive Mechanisms. Speakers will include 1) senior investigators, well established in their fields of maternal, placental and fetal mechanisms of adaptation during pregnancy, 2) young investigators, beginning to forge a successful career in reproductive medicine, and 3) postdocs and graduate students. Poster sessions will provide young investigators a format for direct interaction with conferees. The key note lecture will be "Mechanisms of Placental Angiogenesis", which will have broad interest to the field of perinatal biology. The Workshop Lectures will address "Placental Imaging Techniques" and "Molecular Regulation of Epigenetic Mechanisms". This Conference of basic scientists and clinicians, whose broad interests lie in understanding the mechanisms underlying adverse pregnancy outcomes, is expected to generate new ideas on how to address the impact of intrauterine stress in global health issues such as obesity, diabetes, and cardiovascular disease. PUBLIC HEALTH RELEVANCE: This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This will be a 3d Conference organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the effects of a stressed intrauterine environment on maternal, placental and fetal mechanisms that contribute to altered fetal outcomes.