2010 Mammary Gland Biology GRC

描述(由申请者提供)：本申请寻求为第23-25届戈登乳腺生物学研究会议(GRC)提供三年的资金支持。这个由来已久的会议是为数不多的几个属于乳腺生物学家和乳腺癌研究人员必须参加的年度会议之一。这次会议的目的是将研究整合到乳腺正常发育和环境暴露的潜在机制如何有助于乳腺癌的风险和预防，以及确保高质量的哺乳以满足世界各地儿童的营养需求。这次多学科会议是传播发现的关键会议，这些发现通过将乳腺癌放在正常功能的背景下来揭示它们的异常生物学特征。 独特的戈登会议形式，研究人员每天分享三顿饭，并在一周的工作时间内规定社交时间，这鼓励了友谊和信任，这既促进了深入的讨论，也促进了合作企业的启动。在这个竞争激烈的领域，这也是唯一一次保持披露未发表作品的传统和期望的会议。它还为学生和博士后提供了前所未有的机会和机会，为这一群体的演讲保留了大量的空位。国际参与为独特的视角和合作提供了机会。 由于上述原因，乳腺生物学GRC的名额需求很高，这一事实证明了这是GRC举办的最受欢迎的会议之一。为了满足需求，GRC组织将这次会议安排在他们最大的会场，与大多数GRC不同的是，乳腺生物学GRC每年都会举办，在欧洲和美国之间交替举办，促进国际合作。即使采用年度会议，对会议的需求也经常超过会议场地座位容量的限制。此外，当GRC组织进行民意调查时，大会经常收到与会者的高度赞扬，强调这次会议为与会者提供的高价值。 6年多来，乳腺生物学GRC一直得到美国国立卫生研究院的支持。这种支持为会议的成功奠定了基础。为了确保其成功的连续性，这项提案要求在今后三个会议年提供支持。 与公共健康相关：目前，美国女性患乳腺癌的终生风险为八分之一，预计仅2009年一年就有超过19万例浸润性乳腺癌病例和4万例死亡。虽然在发展中国家发病率较低，但乳腺癌发病率正在以惊人的速度上升，突显了导致乳腺癌的环境和生活方式因素。乳腺生物学戈登研究会议是一个国际会议，致力于(I)了解确保良好哺乳的发育途径，以满足世界各地儿童的营养需求，(Ii)发育途径的扰动和环境暴露如何影响乳腺癌风险，以及(Iii)确定乳腺癌的预防和治疗目标。

DESCRIPTION (provided by applicant): This application seeks three years of funding support for the 23rd-25th Gordon Research Conference (GRC) on Mammary Gland Biology. This long-established conference is one of just a few annual meetings that falls into the "must-attend" class for mammary biologists and breast cancer researchers. The meeting aims to integrate research into the how the mechanisms underlying normal mammary gland development and environmental exposures contribute to both the risk and prevention of breast cancer as well as assuring competent lactation to meet the nutritional needs of children around the world. This multidisciplinary conference is the key meeting for the dissemination of findings that reveal the aberrant biological features of breast cancer by placing them into the context of normal function. The unique Gordon Conference format, where researchers share three meals per day and mandated social time over a working week, encourages the friendship and trust that very fosters both incisive discussions and the initiation of collaborative ventures. It is also the only meeting in this highly competitive field that maintains the tradition and expectation of revealing unpublished work. It also offers students and postdocs unprecedented access and exposure with a large number of slots reserved for presentations by this group. The international participation offers opportunities for unique perspectives and collaborations. For all of the reasons above, the demand for places at the Mammary Gland Biology GRC is high, as evidenced by the fact that it is one of the most popular conferences run by the GRC. To meet demand the GRC organization places this conference in their largest venues, and unlike most GRCs, the Mammary Gland Biology GRC is run every year, alternating between European and US sites fostering international collaborations. Even by adopting annual conferences, demand for the meeting routinely exceeds the limits placed on the conference by venue seating capacity. Further, the conference routinely receives high praise from its attendees when polled by the GRC organization, emphasizing the high value this conference provides to the attendees. The Mammary Gland Biology GRC has received unbroken NIH support for more than 6 years. This support has underpinned the success of the conference. To assure the continuity of its success, this proposal requests support for the next three conference years. PUBLIC HEALTH RELEVANCE: The lifetime risk of developing breast cancer is currently 1 in 8 among women in the U.S.A., with over 190,000 cases of invasive breast cancer and 40,000 deaths expected in 2009 alone. Though less frequent in developing countries the rates of breast cancer are rising at alarming rates underscoring the environmental and lifestyle factors that contribute to breast cancer. The Mammary Gland Biology Gordon Research Conference is an international conference dedicated to (i) understanding the developmental pathways that assure competent lactation to meet the nutritional needs of children around the world, (ii) how perturbations in developmental pathways and environmental exposures affect breast cancer risk and (iii) identify targets for prevention and treatment of breast cancer.