2010 Fibroblast Growth Factors in Development and Diseases Gordon Research Confer

描述（由申请人提供）：本申请申请部分资金支持将于2010年3月14日至19日在加州文图拉的Four Points by Sheraton举行的2010戈登成纤维细胞生长因子在发育和疾病中的研究会议。本次会议的首要目标是加强我们对FGF信号在人类生物学中无处不在的作用的理解。本次会议的主题包括：1)胚胎发育过程中FGF信号调控器官发生和组织模式的机制；2) FGF信号在成人组织稳态、修复、再生和血管生成中的作用；3)内分泌FGFs在调节葡萄糖/脂质/胆汁酸代谢、能量稳态以及磷酸盐/维生素D稳态中的新作用；4) FGF信号与其他形态发生通路，包括Wnt、Hedgehog、BMP信号通路之间的串扰；5)发育/遗传性疾病中FGF信号异常，包括骨骼综合征、听力损失和性腺功能减退；FGF信号在各种癌症中的作用。

DESCRIPTION (Provided by Applicant): This application requests funding to partially support the 2010 Gordon Research Conference on Fibroblast Growth Factors in Development and Disease, to be held on March 14 - 19, 2010, at the Four Points by Sheraton in Ventura, California. The overarching goal of this conference is to enhance our understanding of the ubiquitous roles of FGF signaling in human biology. Among the topics to be covered in this meeting are: 1) the mechanisms by which FGF signaling governs organogenesis and tissue patterning during embryonic development; 2) the role of FGF signaling in adult tissue homeostasis, repair, regeneration, and angiogenesis; 3) the emerging roles of the endocrine FGFs in the regulation of glucose/lipid/bile acid metabolism, and energy homeostasis, as well as in phosphate/vitamin D homeostasis; 4) crosstalk between FGF signaling and other morphogenetic pathways, including Wnt, Hedgehog, and BMP signaling pathways; 5) aberrant FGF signaling in developmental/hereditary diseases, including skeletal syndromes, hearing loss, and hypogonadism; and 6) roles of FGF signaling in various cancers. The five-day conference will be convened in a relatively isolated setting, with 36 invited speakers as well as approximately 15 speakers selected from abstracts that represent current areas of FGF research, and a total of approximately 135 participants. At least one third of the speakers will be women, and female scientists as well as individuals from minority groups will be particularly encouraged to participate. The program will kick off with three featured talks: The first presentation will give a historical update on the discovery of FGFs, the second will summarize the current knowledge on the FGF family, and the third talk will introduce the recently discovered endocrine FGFs. Eight sessions will follow that broadly address structural and biochemical aspects of FGF signaling, as well as the roles of FGFs in organogenesis and tissue patterning, in development and disease of the nervous and sensory systems, in glucose/lipid metabolism and phosphate/vitamin D homeostasis, in the pathogenesis of hereditary/developmental diseases, in tissue repair and regeneration (including stem cell biology), and in tumorigenesis. Reflecting the pleiotropic functions of FGF signaling in human biology, FGF researchers encompass a wide range of scientific disciplines, including structural biologists, biochemists, cell biologists, endocrinologists, developmental biologists, geneticists, pharmacologists, and clinicians. Consequently, the majority of FGF investigators do not attend other common meetings. Thus, the significance of this application is that this Gordon Research Conference on FGFs in Development and Disease will provide an interdisciplinary forum for new as well as established basic researchers, clinicians, and scientists from industry to discuss the latest results, exchange ideas, foster interdisciplinary collaborations, and shape future avenues of research. PROJECT NARRATIVE: The health relatedness of this application is to provide a forum to define and tackle questions pertaining to the human development, metabolism, tissue repair, and human diseases of the nervous and sensory systems, metabolic disorders, skeletal and reproductive diseases, as well as cancer. Moreover, an emphasis will be placed on how to apply the latest discoveries in the field to develop new therapies for a variety of human diseases.