SKELETAL MUSCLE GROUP VIA PHOSPHOLIPASE A2 (IPLA2?): EXPRESSION AND ROLE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 磷脂酶A2（PLA 2s）中有VI类钙离子非依赖性磷脂酶A2（iPLA 2s），并已报道了iPLA 2在骨骼肌中的多个转录本的表达。在本研究中，脂肪酶活性和连续的ATP和钙调素亲和柱层析分析显示骨骼肌iPLA 2表现出iPLA 2 <$亚型的特性。iPLA 2的脂肪酶活性已被证明参与磷脂重塑、信号转导、细胞增殖和凋亡。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Among the phospholipases A2 (PLA2s) are the Group VI Ca2+-independent PLA2s (iPLA2s) andexpression of multiple transcripts of iPLA2 in skeletal muscle has been reported. In the present study, lipaseactivity and sequential ATP and calmodulin affinity column chromatography analyses reveal that skeletal muscleiPLA2 exhibits properties characteristic of the iPLA2¿ isoform. The lipase activity of iPLA2¿ has been demonstrated to participate in phospholipid remodeling, signal transduction, cell proliferation, and apoptosis.