Optimum Thiamine Dose for Treatment and Prevention of Wernicke-Korsakoff Syndrome (WKS): A Randomised Controlled Trial targeting Aboriginal People.

Wernicke-Korsakoff综合征(WKS)曾被认为是一种罕见的疾病，现在已知在营养缺乏或酒精依赖的人中很常见。WKS可能会导致显著的、长期的大脑功能障碍，严重影响工作、个人和社会功能。虽然有效的治疗可以极大地减少严重残疾以及这种疾病的人类和社会成本，但几乎没有证据表明最佳剂量方案。该项目建议开发高质量的证据，以便在土著环境中有效治疗WKS。

Wernicke-Korsakoff syndrome (WKS), once thought to be a rare condition, is now known to be common in people with nutritional deficiencies or alcohol dependence. WKS may lead to significant, long-term brain dysfunction with severe effects on work, personal and social function. Whilst effective treatment may greatly reduce severe disability and the human and social costs of this illness, almost no evidence exists on optimal dosing regimens. This project proposes to develop quality evidence for effective treatment of WKS in an Aboriginal setting.