Optimum thiamine dose for treatment and prevention of Wernicke-Korsakoff Syndrome

Wernicke-Korsakoff综合征（WKS）曾经被认为是一种罕见的疾病，现在人们知道它在营养缺乏或酒精依赖的人群中很常见。WKS可能导致严重的、长期的脑功能障碍，严重影响工作、个人和社会功能。虽然有效的治疗可以大大减少严重残疾以及这种疾病的人类和社会成本，但几乎没有关于最佳给药方案的证据。该项目旨在为土著环境中WKS的有效治疗提供高质量的证据。

Wernicke-Korsakoff syndrome (WKS), once thought to be a rare condition, is now known to be common in people with nutritional deficiencies or alcohol dependence. WKS may lead to significant, long-term brain dysfunction with severe effects on work, personal and social function. Whilst effective treatment may greatly reduce severe disability and the human and social costs of this illness, almost no evidence exists on optimal dosing regimens. This project proposes to develop quality evidence for effective treatment of WKS in an Aboriginal setting.