Tanzania AIDS and TB ICOHRTA

描述（由申请人提供）：坦桑尼亚是撒哈拉以南非洲受艾滋病和结核病影响最严重的国家之一。我们建议培训未来的领导人在坦桑尼亚开展流行病学、业务和卫生服务研究以及艾滋病毒/艾滋病和结核病的临床研究。基于深入的需求评估，我们确定了三个主要领域的培训缺口：(1)研究方法，包括定量、定性和成本效益研究方法；(2)对艾滋病毒/艾滋病和结核病的预防、护理和治疗有实质性的了解；(3)加强研究系统，包括生物伦理、拨款写作和手稿开发方面的培训。这一培训倡议将由穆希比利卫生及相关科学大学和哈佛大学公共卫生学院与国家医学研究所、伊法卡拉卫生研究所、卫生部和坦桑尼亚艾滋病委员会合作开展。在过去的十多年里，我们已经发展了一支多学科的研究团队，他们在发现知识方面进行了先进的研究培训，包括各种干预措施的安全性和有效性。在今后5年中，我们建议将重点放在临床、业务和卫生系统研究领域的能力建设上，以推动实施基于证据的艾滋病毒/艾滋病和结核病最佳实践。培训将在波士顿和达累斯萨拉姆提供，后者在方案的五年期间承担更大比例的培训活动。学员将受益于接触拟议合作伙伴之间广泛的现有合作项目，包括流行病学和实验室研究、随机临床试验、运筹学计划和现有数据集。这些资源将为研究培训提供独特的机会，包括研究设计和实施的实际方面以及数据分析和手稿开发技能的改进。我们将定期监测我们的表现，并努力为坦桑尼亚的可持续培训活动开发一个系统。公共卫生相关性：拟议的培训方案将在流行病学、业务、卫生服务和临床领域培养一支熟练的研究人员骨干队伍，并促进坦桑尼亚艾滋病毒/结核病传染病研究领域的可持续能力。

DESCRIPTION (provided by applicant): Tanzania is one of the most affected countries in sub-Saharan Africa by HIV/AIDS and TB. We propose to train future leaders to conduct research in epidemiological, operations and health services, and clinical research of HIV/AIDS and TB in Tanzania. Based on an in-depth needs assessment we identified training gaps in three principle areas: (1) research methods including quantitative, qualitative, and cost-effectiveness research methods; (2) substantive knowledge of prevention, care and treatment of HIV/AID S and TB; and (3) Research Systems Strengthening that include training on bioethics, grant writing, and manuscript development. This training initiative will be undertaken by Muhimbili University of Health and Allied Sciences and Harvard School of Public Health, in partnership with the National Institute of Medical Research, Ifakara Health Institute, the Ministry of Health, and the Tanzania Commission for AIDS. Over more than a decade, we have developed a multidisciplinary team of investigators that advanced research training related to discovery of knowledge including the safety and efficacy of various interventions. Over the next 5 years we propose to focus on building capacity in the area of clinical, operational, and health systems research that would advance the implementation of evidence-based best practices on HIV/AIDS and TB. Training will be provided in Boston and Dar es Salaam, with the latter assuming greater proportion of the training activities over the five years of the program. Trainees will benefit from exposure to a broad range of existing collaborative projects between the proposed partners including epidemiological and laboratory studies, randomized clinical trials, operations research programs, and existing datasets. These resources will provide unique opportunities for research training, including practical aspects of study design and implementation and refinement of skills in data analysis and manuscript development. We will regularly monitor our performance and strive to develop a system for sustainable training activities in Tanzania. PUBLIC HEALTH RELEVANCE: The proposed training program will develop a cadre of skilled researchers in epidemiological, operations and health services and clinical areas, and facilitate sustainable capacity in the field of HIV/TB infectious disease research in Tanzania.