FASEB SRC on Hematopoietic Malignancies

简介（由申请人提供）：FASEB夏季造血恶性肿瘤研究会议是一个高度集中和互动的医生和科学家会议，他们致力于血液疾病的研究，并致力于为患者开发改进的治疗方法。与每年吸引超过15,000名参与者的美国血液学学会会议不同，FASEB会议限制为175名参与者，因此为学员与该领域的领导者会面提供了一个协作和支持的环境。2011年的会议将重点介绍各种血癌的生物学和治疗方面的最新进展，包括急性髓性白血病、急性淋巴性白血病、骨髓瘤、骨髓增生性肿瘤和骨髓增生性疾病。此外，今年的会议将包括关于造血系统生物学、干细胞生物学和代谢突变在血液恶性肿瘤中的作用的会议。我们将举办特别的“会见专家”和“会见编辑”会议，学员可以与该领域的领导者和《癌细胞》杂志的编辑海伦娜·杨博士进行一对一的互动。2011年的会议将再次在佛蒙特学院举行，这是佛蒙特州农村的一所小型寄宿学校。这个网站是一个理想的环境，因为参与者很少分心，可以全天与学生和博士后互动。会议将强调以下关键领域：1)肿瘤代谢物的鉴定及其对血癌治疗和诊断的意义；2)正常造血干细胞和祖细胞发育对白血病干细胞（LSC）生物学的认识；3)造血肿瘤中转录调控改变的机制，特别关注DNA甲基化、组蛋白乙酰化、甲基化和染色质结构的变化；4) microrna在CLL发病机制中的作用及作为肿瘤生物标志物的作用；5)动物模型使用的经验教训；LSC的鉴定和抗LSC治疗；6)人类基因组计划在血液系统恶性肿瘤研究中的影响，重点是功能基因组学；7)系统生物学方法在造血恶性肿瘤和LSC生物学中的应用；8)基于对疾病分子认识的最新治疗进展；例如T-ALL中的Notch抑制剂；格列卫在慢性髓性白血病中的耐药和敏感机制，三氧化二砷在APL和CLL中的应用，以及JAK抑制剂在骨髓增生性肿瘤中的应用。美国国立卫生研究院的支持将用于为学员和早期研究人员以及一小部分受邀演讲者提供注册和住宿。

DESCRIPTION (provided by applicant): The FASEB Summer Research Conference on Hematopoietic Malignancies is a highly focused and interactive meeting of physicians and scientists who are dedicated to the study of blood diseases and are committed to developing improved therapies for patients. Unlike the annual American Society of Hematology Meeting, which draws well over 15,000 participants, the FASEB meeting, is restricted to 175 attendees and thus provides a collaborative and supportive environment for trainees to meet with leaders in the field. The 2011 meeting will highlight recent advances in biology and treatment of a wide spectrum of blood cancers, including acute myeloid leukemia, acute lymphoid leukemia, myeloma, myeloproliferative neoplasms and myeloproliferative diseases. In addition, this year's meeting will include sessions on systems biology of hematopoiesis, stem cell biology, and the role of metabolic mutations in hematologic malignancies. We will hold special "Meet the Expert" and "Meet the Editor" sessions, where trainees can interact one on one with leaders in the field and with Dr. Helena Yang, editor of the journal Cancer Cell. The site of the 2011 meeting will once again be the Vermont Academy, a small boarding school in rural Vermont. This site is an ideal setting, because the participants have few distractions and are available to interact with students and post-docs throughout the day. The meeting will emphasize the following key areas: 1) The identification of oncometabolites and their implications for blood cancer treatment and diagnosis; 2) Normal hematopoietic stem and progenitor cell development for understanding leukemia stem cell (LSC) biology; 3) Mechanisms of altered transcriptional regulation in hematopoietic neoplasms, with a particular focus on changes in DNA methylation as well as histone acetylation, methylation and chromatin structure; 4) Role of microRNAs in CLL pathogenesis and as cancer biomarkers; 5) Lessons learned from the use of animal models; identification of LSCs and anti- LSC therapies; 6) The impact of the human genome project in investigations of hematological malignancies, with an emphasis on functional genomics; 7) Application of systems biology approaches to hematopoietic malignancies and LSC biology; and 8) Recent therapeutic advances based on a molecular understanding of the diseases; e.g. Notch inhibitors in T-ALL; mechanisms of Gleevec resistance and sensitivity in chronic myeloid leukemia, use of arsenic trioxide in APL and CLL, and efforts to utilize JAK inhibitors in myeloproliferative neoplasms. Support from the NIH will be used to provide registration and lodging for trainees and early stage investigators and a small subset of invited speakers. PUBLIC HEALTH RELEVANCE: Although there have been major breakthroughs in treating a few subtypes of hematologic malignancies, such as the use of Gleevec in chronic myeloid leukemia, the majority of blood cancers remain major causes of morbidity and mortality of both adult and pediatric patients. The FASEB Summer Research Conference on Hematopoietic Malignancies serves to bring together basic, translational, and clinical researchers for an insightful and productive exchange of latest discoveries. The meeting also fosters new collaborations and the training of graduate students, post---doctoral fellows and early stage investigators in this important research field.