FASEB SRC on Genetic Recombination and Genome Rearrangements

描述（由申请人提供）：本申请为将于2011年7月24日至29日在科罗拉多州蒸汽船泉举行的美国实验生物学协会联合会（FASEB）基因重组和基因组重排会议寻求部分支持。2011年基因重组和染色体重排会议将是一系列非常成功的双年会中的第十四次会议，专门讨论这些主题。这次会议的目的是让研究人员在一系列生物系统和不同实验方法中研究基因重组的许多不同方面。报告将介绍有关该领域及时问题的新的和未发表的工作，并将包括所有参与者的讨论。FASEB会议为信息和技术交流提供了独特的机会，这些信息和技术可以在整个重组领域得到重视和利用。重组在人类和其他生物的遗传稳定性控制中起着重要的作用。研究发现，双链断裂修复缺陷可导致一些人类易患癌症的综合征，如失联性毛细血管扩张症（Ataxia telangi扩张症，A-T）、奈梅根断裂综合征（Nijmegen broken Syndrome， NBS）和A-T样疾病（A-TLD），这一发现凸显了该途径在维持基因组完整性和避免癌症方面的重要性。此外，BRCA2基因的产物，在遗传性乳腺癌的一个亚群中发生突变，直接与Rad51相互作用，对同源重组至关重要。许多受邀演讲者将讨论这些人类癌症易感综合征中蛋白质缺陷在基因组稳定性和对环境诱变剂的抗性中的作用。为了增加哺乳动物的研究，将介绍细菌、酵母、拟南芥、果蝇、秀丽隐杆线虫和爪蟾模型系统中相关蛋白质和机制的研究。会议的大部分时间将专门讨论国家癌症协会关心的话题。

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held July 24-29, 2011 in Steamboat Springs, Colorado. The 2011 Conference on Genetic Recombination and Chromosome Rearrangements will be the fourteenth in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. Recombination plays an important role in the control of genetic stability in human as well as all other living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), Nijmegen Breakage Syndrome (NBS) and A-T like disorder (A-TLD), are caused by defects in double-strand break repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. Furthermore, the product of the BRCA2 gene, which is mutated in a subset of hereditary breast cancers, interacts directly with Rad51 and is essential for homologous recombination. Many of the invited speakers will discuss the role of proteins defective in these human cancer prone syndromes in genome stability and resistance to environmental mutagens. To inform and augment studies from mammals, work concerning related proteins and mechanisms from model systems of bacteria, yeast, Arabidopsis, Drosophila, C. elegans and Xenopus will be featured. Much of the conference will be devoted to topics of concern to the National Cancer. PUBLIC HEALTH RELEVANCE: DNA repair by homologous recombination plays an important role in the control of genetic stability in all living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), hereditary forms of breast cancer (BRCA1 or BRCA2) and Bloom's syndrome are caused by defects in the DNA recombination/repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. This conference brings together the principal investigators studying the mechanisms of recombination with the goal of further understanding how recombination contributes to genome stability.