Cortical Potentials and Speech Perception in Children with Auditory Neuropathy

描述(由申请人提供)：患有听神经病谱系障碍的儿童对早期干预和康复提出了挑战，因为这种障碍的多样性，以及目前缺乏强有力的指标来指导这一人群的管理。这些挑战可能导致在选择和实施适当干预措施方面出现重大延误，例如助听器和/或人工耳蜗植入。本项目主要研究皮层听觉诱发电位作为一类客观的电生理指标，在预测干预结果方面有很大的希望。这项拟议的工作通过追求两个具体目标来评估患有这种障碍的儿童的这些潜力和言语感知之间的联系。目的1以使用助听器的儿童为研究对象，评估听觉诱发皮层电位在预测助听器使用成功方面的作用。目的2以人工耳蜗术后儿童为研究对象，探讨电诱发皮层电位与言语知觉的关系。将记录每个儿童的皮层电位(P1-N1-P2复合波和变化复合波)，以响应他们的设备的适当的声音或电刺激。此外，还将使用适合年龄和发育的测试来衡量辅助语音感知性能。然后将评估电生理测量和语音感知性能之间的相关性。这些实验的目标是确定在指导干预策略方面最具信息量的电生理反应特征。因此，这个项目具有巨大的翻译意义，因为它的发现可能直接影响临床实践。 公共卫生相关性：旨在评估听神经病频谱障碍(ANSD)儿童皮层诱发电位的电生理测量与言语感知能力之间的关系。这项拟议研究的最终目标是开发工具，以便及早准确地确定每个患者的最佳康复策略。本研究中所研究的电生理方法有可能作为ANSD患者临床试验的一部分，对临床实践产生重要影响。

DESCRIPTION (provided by applicant): Children with Auditory Neuropathy Spectrum Disorder present a challenge for early intervention and habilitation because of the diversity of the disorder and the current lack of robust indicators to guide in management of this population. These challenges can result in significant delays in selecting and implementing appropriate interventions such as hearing aids and/or cochlear implants. This project focuses on cortical auditory evoked potentials as a class of objective electrophysiological measures that hold great promise in the prediction of intervention outcomes. The proposed work evaluates the association between these potentials and speech perception in children with this disorder by pursuing two specific aims. Aim 1 focuses on the sub- group of children who use hearing aids and evaluates the utility of acoustically-evoked cortical potentials for predicting success with these devices. Aim 2 focuses on the sub-group of children who use cochlear implants and evaluates the relationship between electrically-evoked cortical potentials and speech perception. Cortical potentials (P1-N1-P2 complex and the change complex) will be recorded from each child in response to either acoustical or electrical stimulation, as appropriate for their device. In addition, aided speech perception performance will be measured using age- and developmentally-appropriate tests. Correlations between the electrophysiological measures and speech perception performance will then be assessed. The goal of these experiments is to identify electrophysiological response features that are most informative in terms of guiding intervention strategy. As such, this project has tremendous translational significance because its findings are likely to directly impact clinical practice. PUBLIC HEALTH RELEVANCE: Experiments are proposed to evaluate the relationship between the electrophysiological measures of cortical evoked potentials and the speech perception performance in children with auditory neuropathy spectrum disorder (ANSD). The ultimate goal of the proposed study is to develop tools for early and accurate identification of the best rehabilitative strategy for each individual patient. It is likely that the electrophysiological measures investigated in this program of research might be adopted as part of clinical test-battery for ANSD patients, which will have an important impact on clinical practice.