Translational Research in Surgical Oncology

描述(申请人提供)：美国每年将有100多万人罹患癌症，其中约一半人将死于癌症。尽管人们在预防癌症方面做出了重大努力，但对非转移性疾病的有效早期诊断和治疗仍然是现代有效癌症管理的标志。外科手术仍然是癌症治疗的主要诊断和治疗手段，外科技术的进步(如正常和病变组织的光纤和放射性核苷酸可视化以及仪器的小型化和机器人控制)有助于改善对癌症患者的护理。然而，对疾病的生物学基础以及在多学科背景下对癌症的有效诊断和治疗管理的理解将在未来十年带来最大的进步。在当前的发现时代，对外科医生进行癌症生物学基础的教育和培训的机会是前所未有的。肿瘤遗传学、细胞生物学和免疫学的进展为癌症研究的基础研究、翻译研究和临床研究提供了重要机遇。这一教育和培训未来几代外科科学家和领导者的机会为申请外科肿瘤学转化性研究的培训拨款提供了令人信服的必要性。

DESCRIPTION (provided by applicant): Over one million Americans will suffer from cancer every year, and approximately half of them will die from the disease. Despite major efforts to prevent cancer, effective early diagnosis and treatment of non- metastatic disease remains the hallmark of modern effective cancer management. Surgery persists as a major diagnostic and therapeutic modality for the management of cancer and advances in the technology of surgical technique (such as fiber-optic and radio-nucleotide visualization of normal and diseased tissue and miniaturization and robotic control of instruments) have contributed to the improved care of the cancer patient. Nonetheless, it is an understanding of the biologic basis of the disease and the effective diagnostic and therapeutic management of cancer within a multidisciplinary context that will bring the greatest advances over the next decade. In the current era of discovery, the opportunities for the education and training of surgeons in the biologic basis of cancer are unprecedented. The advances in cancer genetics, cell biology and immunology provide important opportunities for basic, translational and clinical studies in cancer research. This opportunity to educate and train future generations of surgical scientists and leaders provided a compelling imperative for this application for a training grant in translational studies in surgical oncology.