Highly efficient, compact, picosecond green laser for time resolved fluorescence

描述（由申请人提供）：第一阶段工作的主要目标是建立制造波导的可行性，以实现皮秒脉冲绿色激光器的输出功率的性能的显著（10倍）增加，而不增加峰值泵浦功率。最终的目标是开发一个光纤尾纤，紧凑，具有成本效益的530 nm皮秒激光器，在80 MHz时产生10 mW的平均功率。除了通过更高的输出功率和更高的脉冲重复频率实现更灵活的激光源之外，更高的效率使得能够通过使用更低功率、更低成本的泵浦来制造更低成本的1 mW平均功率激光器。提高整体性能（增加功率，脉冲重复频率和寿命，减少尺寸和成本）将显着增加该技术纳入广泛的时间分辨生物科学应用，从而有助于加速新的生物科学突破。在第一阶段的工作中，AdvR将利用其在非线性光学频率转换器方面的经验，制造改进的倍频波导，从而在使用PicoQuant MOFA 1064脉冲激光器时，使脉冲输出功率从目前的1 mW平均功率（40 MHz）显著增加。这项工作的关键创新是将联合收割机三种高回报的制造方法结合起来，以提高二次谐波发生模块的效率。它们是：1）使用锥形掩埋波导结构来显著降低输入和输出耦合损耗（从50%到20%），2）通过优化波导几何形状（宽度和深度）来将内部波导转换效率从100%/W/cm 2增加到300%/W/cm 2，以及3）增加波导的总长度（从1.5cm增加到3cm）。 公共卫生相关性：生物科学需要发展时间分辨技术，以在分子水平上研究细胞功能。SBIR的最终目标是开发一种带尾纤的、紧凑的、具有成本效益的530 nm皮秒激光器，在80 MHz时产生10 mW的平均功率。更高的平均功率将提供更灵活的激光源，从而为各种生物科学应用提供更高的脉冲重复频率和测量速度。此外，更高效的波导倍增器将需要更少的泵浦功率来满足当前1 mW的平均功率输出规格，这将大大增加整个激光系统的寿命，并降低泵浦激光器的要求和成本，使更多的研究人员能够负担得起进行时间分辨荧光研究的设备，加速生物科学的突破。

DESCRIPTION (provided by applicant): The primary goal of the Phase I effort is to establish the feasibility of fabricating waveguides to realize a significant, (10 fold), increase in performance in the output power of a picosecond pulsed green laser without increasing the peak pump power. The ultimate goal is to develop a fiber pigtailed, compact, cost-effective 530 nm picosecond laser producing 10 mW average power at 80 MHz. In addition to achieving a more flexible laser source through higher output powers and higher pulse repetition frequencies, the higher efficiency enables the manufacture of lower cost 1 mW average power lasers by using lower power, lower cost pumps. Improving the overall performance (increased power, pulse repetition frequency and lifetime with reduced size and cost) will significantly increase the incorporation of this technology into a broad range of time-resolved bioscience applications and thus helping to accelerate new bioscience breakthroughs. In the Phase I effort, AdvR will utilize its experience with nonlinear optical frequency converters to fabricate improved frequency doubling waveguides resulting in a significant increase in pulsed output power from the current 1 mW average power at 40 MHz when using a PicoQuant MOFA 1064 pulsed laser. The key innovation in this effort is to combine three high payoff manufacturing approaches to increasing the second harmonic generation module's efficiency. They are: 1) using tapered, buried waveguide structures to significantly decrease input and output coupling losses (from 50% to 20%), 2) increasing internal waveguide conversion efficiency from 100%/W/cm2 to 300%/W/cm2 by optimizing the waveguide geometry (width and depth), and 3) increasing the overall length of the waveguide (from 1.5cm to 3cm). PUBLIC HEALTH RELEVANCE: The biosciences require the development of time-resolved techniques to investigate cellular functions at the molecular level. The ultimate goal of this SBIR effort is to develop a fiber pigtailed, compact, cost-effective 530 nm picosecond laser producing 10 mW average power at 80 MHz. The higher average power will provide a more flexible laser source, enabling higher pulse repetition frequencies and measurement speed for a variety of bioscience applications. In addition, more efficient waveguide doublers will require less pump power to meet the current 1 mW average power output specification, which will dramatically increase the lifetime of the overall laser system and decrease the pump laser requirements and cost, allowing more researchers to afford the equipment to carry out time-resolved fluorescence research, accelerating bioscience breakthroughs.