ANTERIOR CINGULATE DEFICITS IN OBSESSIVE-COMPULSIVE DISORDER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究将利用扩散张量成像和功能磁共振成像对40名强迫症(OCD)儿童患者和40名健康志愿者的前扣带回进行研究。受试者还将提供DNA，以研究强迫症患者大脑异常的遗传基础。我们希望加深对前扣带回在强迫症神经生物学中的作用的理解，以及该区域的异常是否可以作为强迫症遗传学研究的内表型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current study will utilize diffusion tensor imaging and functional magnetic resonance imaging to investigate the anterior cingulate in 40 pediatric patients with obsessive compulsive disorder (OCD) and 40 healthy volunteers. Subjects will also provide DNA to investigate the genetic basis of brain abnormalites in OCD. We hope to improve our understanding of the role that the anterior cingulate plays in the neurobiology of OCD and whether abnormalities in this region can serve as endophenotypes in genetic studies of the disorder.