ANALYSIS OF GENE EXPRESSION IN OSTEOPHYTES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该方案提出测量骨赘中的基因表达模式，以确定骨赘形成的遗传基础。 具体来说，研究人员将测量从接受全膝关节置换术的患者中收集的组织中的RNA（微阵列筛选）。将比较骨赘、正常关节软骨和退行性软骨之间的RNA表达模式。将通过组织捐赠计划收集样本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol proposes to measure gene expression patterns in osteophytes to determine the genetic basis for osteophyte formation. Specifically, the investigators will measure RNA (microarray screening) in tissue collected from patients undergoing total knee replacements. Patterns of RNA expression will be compared between osteophytes, normal articular cartilage, and degenerative cartilage. Samples will be collected through the Tissue Donation Program.