DOES SMALL INTESTINAL BACTERIAL OVERGROWTH CONTRIBUTE TO FUNCTIONAL DYSPEPSIA?

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该研究的目的是测试SIBO在FD中的作用。测试顺序如下：1.比较FD患者与健康对照者乳果糖呼气试验异常的患病率，2.比较FD患者与健康对照者对营养饮料试验的耐受量，3.比较症状评分和？停止音量？在一项随机、双盲、安慰剂对照研究中，FD患者在抗生素治疗前后进行营养饮料试验。我们将使用随机对照试验的最佳设计，而不是随机交叉试验、队列研究或病例对照研究，以达到尽可能消除任何混杂因素或偏倚影响的目的。 具体目标1：我们将确定FD中SIBO和超敏反应的患病率和相关性 具体目标2：我们将使用随机抗生素治疗来确定SIBO与FD超敏反应之间的关系。 I D.设计（包括研究者是否发起的多中心、初步研究、设盲、随机、涉及安慰剂、研究分期、预防研究）： 这是一项由研究者发起的初步研究，旨在为随后的NIH R 01功能性消化不良申请收集数据。本项目拟采用随机、安慰剂对照、设盲设计。如果中心假设得到证实，那么很大比例的功能性消化不良患者的症状在研究期间应该得到缓解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the study is to test the role of SIBO in FD. The order of testing will be as follows: 1. Compare prevalence of abnormal lactulose breath test in patients with FD vs. healthy controls, 2. Compare the volume of tolerance to nutritive drink test in patients with FD vs. healthy controls, 3. Compare symptom score and ?stop volume? for a nutritive drink test in FD patients before vs. after antibiotic treatment in a randomized, double, blind, placebo-controlled study. We will use the best possible design of a randomized controlled trial rather than a randomized crossover trial, a cohort study or a case-control study to achieve the aim of eliminating as much as possible the effect of any confounding factor or bias. Specific Aim 1: We will determine the prevalence and association of SIBO and hypersensitivity in FD Specific Aim 2: We will determine the relationship between SIBO and hypersensitivity of FD using randomized antibiotic treatment. I D. Design (include things like whether the study is investigator initiated multi-center, pilot study, blinded, randomized, involves placebo, phase of study, prevention study): This is an investigator initiated pilot study to collect data for a subsequent NIH R01 application on Functional Dyspepsia. The project proposed involves a randomized, placebo-controlled, blinded design. If the central hypothesis is confirmed, a significant proposportion of patients presenting with functional dyspepsia should experience relief of symptoms within the study period.