TRIAD Legacy Study allowing additional analyses of TRIAD dataset to be performed

项目描述：该应用程序提出了6个分析建议，这些建议利用了2000年至2006年间作为TRIAD研究的一部分收集的数据。TRIAD是一项多中心前瞻性队列研究。它包括2000-2001年期间在基线（第1轮）收集的约12,000人的数据，18个月后从2002-2003年期间约9,000名原始参与者收集的随访数据（第2轮），以及2005年期间从原始队列参与者中收集的约6,000人的第二次随访（第3轮）数据。还从健康计划、供应商团体和个人供应商收集数据。此外，第四项调查，即心血管风险调查，针对心血管疾病事件高风险人群和对照组控制良好的患者。这些集中的调查在设计上是横断面的，主要关注中间结果差的原因（即A1C、血压和LDL-C控制水平差）。在2005-2006年期间收集了1137人的数据。通过计算机辅助电话访谈（CATI）和邮寄问卷收集患者资料，以优化应答率。这里提出的6个分析是遗留研究的一部分，旨在扩展可以从数据集提出的科学问题。在印第安纳大学（IU） TRIAD站点，我们选择主要关注心血管风险调查，以解决以下问题并阐明以下问题：1)糖尿病成人心血管疾病风险因素控制的相关因素是什么；2)患者认为的药物使用障碍在心血管疾病结局中的作用是什么？3)患者风险感知与心血管危险因素控制的相关性；4)了解医生对口服高血糖失败的2型患者启动或不启动胰岛素的决定。此外，IU TRIAD网站还将评估与IU TRIAD合作健康计划一起进行的两项试点干预措施；1)评估一项试点干预措施对改善自我报告有遵医嘱服药障碍的糖尿病成人的药物依从性的影响；2)在3个卫生保健系统中实施临床-社区联系预防2型糖尿病的过程和结果。

DESCRIPTION OF THE PROJECT: This application presents 6 analyses proposals that utilize data collected as part of the TRIAD study between 2000 and 2006. TRIAD is a multicenter prospective cohort study. It includes data collected at baseline (round 1) from approximately 12,000 individuals during 2000-2001, follow-up data (round 2) collected 18-months later from approximately 9,000 of the original participants during 2002-2003, and a second follow-up (round 3) collected data from approximately 6,000 individuals of the original cohort of participants during 2005. Data were also collected from health plans, provider groups, and individual providers. In addition, a fourth survey, the Cardiovascular Risk Survey, targeted those at high risk for CVD events and a comparison group of well-controlled patients. These focused surveys are cross-sectional in design and focus on reasons for poor intermediate outcomes (i.e., poor levels of control of A1C, blood pressure, and LDL-C). Data were collected from 1,137 individuals during 2005-2006. Patient data were collected via computer assisted telephone interviews (CATI) and mailed questionnaires to optimize response rates. The 6 analyses proposed here are part of a legacy study that seeks to extend the scientific questions that can be asked from the data sets. At the Indiana University (IU) TRIAD site, we have elected to focus primarily on the Cardiovascular Risk Survey to address the following questions and illuminate the following issues: 1) What are the correlates of CVD risk factor control in adults with diabetes; 2) What is the role that patient-perceived barriers to medication use play in CVD outcomes; 3) What is the correlation between patients risk perception and control of cardiovascular risk factors; and 4) Understanding physicians' decisions to initiate or not initiate insulin in type 2 patients who are oral hyperglycemic failures. In addition, the IU TRIAD site will also evaluate two pilot interventions that were conducted with the IU TRIAD collaborating health plans; 1) Evaluating the impact of a pilot intervention to improve medication adherence in diabetic adults with self-reported barriers to taking medications as prescribed by their providers, 2) Process and outcomes of efforts to implement clinic-community linkages to prevent Type 2 diabetes in 3 systems of health care.