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Pathogenesis and Treatment of HIV Infection

Pathogenesis and Treatment of HIV Infection
HIV感染的发病机制和治疗
批准号：
8148396
负责人：
HENRY C LANE
金额：
$207.39万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8148396
关键词：
HIV InfectionsPathogenesis

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中文摘要
翻译
对HIV感染患者间歇性周期给予白细胞介素-2（IL-2）与外周血CD 4 + T淋巴细胞数量的大量持续增加有关。 尽管受HIV影响的免疫系统的关键因素增加，但IL-2治疗与临床获益无关，如总死亡率和新的AIDS定义疾病的数量所定义的。 当IL-2与抗逆转录病毒治疗一起使用时，IL-2诱导的CD 4 + T细胞增加更好地维持。 发现干扰素-α具有上级于AZT的抗逆转录病毒活性。 这种活性是短暂的，与对干扰素-α耐药的HIV株的发展无关。
英文摘要
The administration of intermittent cycles of interleukin-2 (IL-2) to patients with HIV infection was found to be associated with substantial and sustained increases in the number of peripheral blood CD4+ T lymphocytes. Despite these increases in the critical element of the immune system affected by HIV, IL-2 therapy was not associated with clinical benefit as defined by overall mortality and number of new AIDS-defining illnesses. CD4+ T cell increases induced by IL-2 were better maintained when IL-2 was used together with antiretroviral therapy. Interferon-alpha was found to have antiretroviral activity superior to that of AZT. This activity was transient and not associated with the development of strains of HIV resistant to Interferon-alpha.
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会议论文
IMMUNOLOGIC APPROACHES TO THE THERAPY OF HIV-1 INFECTION
Epi, Pathogenesis, Treatment and Prevention of Diseases
Pathogenesis, Treatment and Prevention of Emerging Infectious Diseases
Immunologic Approaches to the Therapy of HIV-1 Infection
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