ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS

化学物质的吸收、分布、代谢、排泄(ADME)和毒代动力学(TK)研究对于优化设计和解释啮齿动物毒性和致癌性研究是必要的。设计研究的目的是为了加强我们对确定化学毒性的结构-活性关系的了解，并提供基本信息，以支持更准确的实验室数据外推，以评估人类健康风险。根据该合同进行的机理研究提供了与化学物质对啮齿动物的毒性影响有关的基本信息，从而有助于对人类的推断。

Absorption, distribution, metabolism, excretion (ADME) and Toxicokinetic (TK) studies of chemicals are necessary for the optimal design and interpretation of rodent toxicity and carcinogenicity studies. Studies are designed with the intent of enhancing our knowledge on structure-activity relationships that determine chemical toxicity and provide basic information to support more accurate extrapolation of laboratory data to assess human health risks. The mechanistic studies performed under this contract provide basic information related to toxic effects of chemicals in rodents thus aiding the extrapolation to humans.