Training Grant In Radiation Biology

描述（由申请人提供）：美国癌症协会估计，每年有150万美国公民被诊断患有癌症。大约50%的这些癌症患者将接受放射治疗，这可以提供明确的局部区域肿瘤控制，从而为这些患者提供持久的无进展生存期。不幸的是，许多肿瘤对辐照没有反应。阐明放射治疗无法控制肿瘤生长的分子机制需要对放射生物学有一个批判性的理解，放射生物学是一门多学科的科学，研究物理、生物学和医学，因为它涉及肿瘤发生、肿瘤生物学和正常组织生理学。尽管放射生物学对支持放射肿瘤学的使命很重要，但在这个国家，这样的培训项目很少。本培训基金的目标是继续培养博士后在放射生物学领域进行独立研究，使其在放射肿瘤学和癌症生物学领域做出突出贡献。我们建议采用多方面的方法来实现这一目标，包括：1)在实验室中对使用尖端技术的杰出科学家进行培训，并结合高度合作的方法；2)旨在促进基础科学家与从事转化研究的临床医生/科学家之间互动的多学科系列研讨会；3)辐射生物学、辐射物理学和癌症生物学领域的教学培训；4)拨款写作研讨会；5)专业发展，6)实验室管理培训，7)负责任的研究行为培训。学员必须在进入课程之前完成医学博士和/或博士学位。该项目旨在培训3名研究员，为期2至3年。预计其中2名学员将刚刚完成博士或医学博士学位，第三名学员将在进入我们的项目之前拥有2或3年的博士后经验。迄今为止，完成终身教授培训的受训者中，有70%的人有望在制药公司担任助理教授、科学家或放射肿瘤学住院医师，并有望获得教职。值得注意的是，接受这个项目邀请的学员中有30%是少数族裔。基于这些成功，我们认为这个培训资助项目正在实现国家Ruth L. Kirschstein国家研究服务奖的目标。

DESCRIPTION (provided by applicant): The American Cancer Association estimates that 1.5 million citizens of the US are diagnosed with cancer each year. Approximately 50% of these cancer patients will undergo radiation therapy, which can provide definitive local regional tumor control, thus affording these patients with a durable progression free survival. Unfortunately, many tumors do not respond to irradiation. Elucidating the molecular mechanisms responsible for radiation therapy's failure to control tumor growth requires a critical understanding of Radiation Biology, a multi- disciplinary science that studies physics, biology, and medicine as it pertains to oncogenesis, tumor biology and normal tissue physiology. As important as Radiation Biology is for supporting Radiation Oncology's mission, there are very few such training programs in this country. The goal of this training grant is to continue to teach Postdoctoral Fellows to perform independent research in the area of Radiation Biology, so that they can make outstanding contributions to the fields of Radiation Oncology and Cancer Biology. We propose to accomplish this using a multi-faceted approach consisting of 1) training in the laboratories of outstanding scientists who utilize cutting edge techniques coupled with highly collaborative approaches, 2) multi- disciplinary seminar series designed to foster interactions between basic scientists and clinician/scientists who perform translational research, 3) didactic training in the areas of Radiation Biology, Radiation Physics, and Cancer Biology, 4) a grant writing workshop, 5) professional development, 6) training in laboratory management, and 7) Training in the Responsible Conduct of Research. Trainees must have completed a MD and/or a PhD prior to entering the program. The program is designed to train 3 Fellows for a duration ranging from 2 to 3 years. It is anticipated that 2 of the trainees will have just completed their PhD or MD and the third trainee will have 2 or 3 years Post Doctoral experience prior to entering our program. To date 70% of trainees who complete training tenure track assistant professors, staff scientists at pharmaceutical companies, or Radiation Oncology Residents on track to attain faculty positions. Of note, 30% of the trainees who have accepted offers to this program have been underrepresented minorities. Based on these successes, we submit that this training grant program is fulfilling the goals of the National Ruth L. Kirschstein National Research Service Award.