SARRP 200 Small animal radiation research platform

 描述（由申请人提供）：本共享仪器申请用于支持购买小动物辐射研究平台（SARRP）。Xstrahl提供的技术是独一无二的，它将锥形束CT与计算机控制的旋转治疗X射线管相结合。与治疗计划软件相结合，该硬件允许三维放射治疗计划和递送，以模拟用于治疗人类肿瘤的体积方法的生物模型。这种新一代系统利用小动物CT的最新进展来生成真正的图像引导放射治疗或IGRT。该设备结合了一个360 °旋转机架和一个在3个维度上旋转和平移的载物台，以允许从任何角度输送多个X射线子束并会聚在肿瘤上。该系统将取代俄亥俄州州立大学现有的技术，该技术基于50年前的箱式X射线机设计。俄亥俄州州立大学的箱式X射线设备是一台RS2000，一台固定在密封柜顶部的点源X射线发生器。为了治疗动物，必须使用铅屏蔽的手动放置，以屏蔽小鼠的一部分并允许X射线仅输送到模型肿瘤。SARRP将加强6个主要用户的研究，其中9个目前资助的NIH项目涵盖OSUCCC的放射肿瘤学，神经外科学，分子病毒学，免疫学和医学遗传学部门以及全国儿童研究所的实验治疗学项目。此外，SARRP设备将被纳入放射肿瘤学系医学物理学研究生课程的培训中。最后，SARRP将结合到OSU神经科学中心（P30）提供的原位脑肿瘤植入核心服务中。该核心旨在支持治疗脑肿瘤的新技术的开发。目前和未来的研究人员使用这个核心现在将能够将放射治疗与他们的新模式结合起来，希望产生创新的协同疗法来治疗脑肿瘤。

 DESCRIPTION (provided by applicant): This shared instrument application is to support the purchase of a small animal radiation research platform (SARRP). The technology available from Xstrahl is unique and combines a cone beam CT with a computer controlled rotating treatment x-ray tube. In combination with the treatment planning software, this hardware allows for 3-dimensional radiotherapy treatment planning and delivery to model organisms that mimics the volumetric approach used to treat human tumors. This next-generation system leverages the recent advances in small animal CT to generate true image guided radiotherapy, or IGRT. The device incorporates a 360o rotating gantry with a stage that rotates and translates in 3 dimensions to allow for multiple x-ray beamlets to be delivered from any angle and converge upon the tumor. This system will replace the current technology at Ohio State University that is based on 50 year old design for cabinet X-ray machines. The cabinet x-ray device at Ohio State University is an RS2000, a point source X-ray generator fixed to the top of a sealed cabinet. In order to treat animals, one must use manual placement of lead shielding in such a way as to shield a portion of the mouse and allow x-ray delivery only to the model tumor. The SARRP will enhance the research of 6 major users with 9 currently funded NIH projects that span the departments of Radiation Oncology, Neurosurgery, and Molecular Virology, Immunology and Medical Genetics at OSUCCC and the Experimental Therapeutics program at Nationwide Children's Research Institute. In addition, the SARRP device will be incorporated into the training for the graduate program in medical physics run in the department of Radiation Oncology. Finally, the SARRP will be combined into the services that are offered at the OSU Neuroscience Center (P30) core for orthotopic brain tumor implantation. This core is designed to support the development of new technologies for the treatment of brain tumors. Current and future investigators using this core will now be able to incorporate radiotherapy with their novel modalities in the hope of generating innovative, synergistic therapeutics to treat brain tumors.