Immunobiology of Blood and Vascular Systems Training Program

描述（由申请人提供）：重新提交的续期申请要求继续支持范德比尔特大学血液和血管系统免疫生物学（IBVSTP）的完善，充满活力和富有成效的培训计划。IBVSTP专注于炎症作为疾病的主要机制，这些疾病显着改变血液和血管系统，以应对各种微生物，自身免疫和代谢损伤。这个创新的指导和研究生，包括双学位学生和博士后研究员的职业发展培训平台已经证明了其有效性，这是由代表8个基础科学和临床部门的21名教师研究人员的富有成效的合作和出版物数量迅速增长所证明的。该名册允许IBVSTP促进炎症介导的疾病的细胞和分子研究转化为创新疗法的临床前研究。自成立以来，形成了一个迄今为止尚不存在的平台，用于教员导师和学员在主题“亲和组”内的有效互动，包括：（1）脓毒症和肺/心血管感染中的先天免疫和炎症;（2）动脉粥样硬化、自身免疫、高血压、代谢综合征和移植中的促炎性T和B淋巴细胞信号传导和基因表达;（3）造血细胞发育、运输和粘附;（4）炎症和自身免疫中的细胞外基质建模;以及（5）功能基因组学、表观遗传学、蛋白质组学、结构生物学和用于蛋白质组恢复的细胞内肽/蛋白质递送 疗法自2006年更新以来，这些概念和尖端技术资源为14名博士预科生和19名博士后学员，包括来自代表性不足群体的学员，提供了增强实践研究经验和职业发展的巨大机会。该计划的旗舰课程“功能基因组学和蛋白质组学：应用于免疫生物学”提供了统一的教学平台。关于负责任的研究行为的机构课程由具体方案的讨论小组补充。通过请求5个博士前和5个博士后实习生名额，我们回应了学术界日益增长的培训需求。IBVSTP指导委员会在选择培训候选人时采用严格的录取标准，包括强调拟议项目的翻译目标，并评估学员的表现。博士研究生和/或医学博士学位是由IBVSTP指导委员会审查后任命的，并由代表该计划的亲和团体的指导团队提供建议。外部顾问和顾问的投入以及学员的持续反馈提供了额外的培训质量检查点，增强了该计划在基础，转化和临床研究方面为下一代研究人员做好准备的良好记录，这些研究重点是炎症作为影响血液和血管系统的疾病的主要机制。

DESCRIPTION (provided by applicant): This resubmission of the renewal application requests continued support for a well-established, vibrant and productive Training Program in the Immunobiology of Blood and Vascular Systems (IBVSTP) at Vanderbilt University. IBVSTP is focused on inflammation as the major mechanism of diseases that significantly alter blood and vascular systems in response to diverse microbial, autoimmune, and metabolic insults. This innovative training platform for mentoring and career development of graduate students, including dual degree students, and postdoctoral fellows has proven its effectiveness as attested by a rapidly growing number of fruitful collaborations and resulting publications from 21 faculty investigators who represent 8 basic science and clinical departments. This roster allows IBVSTP to facilitate translation of cellular and molecular studies of inflammation-mediated disorders into preclinical studies of innovative therapies. Since its inception, a hitherto non-existent platform was formed for effective interactions of faculty preceptors and trainees within thematic "affinity groups" encompassing: (1) Innate immunity and inflammation in sepsis and pulmonary/cardiovascular infections; (2) Proinflammatory T and B lymphocyte signaling and gene expression in atherosclerosis, autoimmunity, hypertension, metabolic syndrome, and transplantation; (3) Hemopoietic cell development, trafficking, and adhesion; (4) Extracellular matrix modeling in inflammation and autoimmunity; and (5) Functional genomics, epigenetics, proteomics, structural biology, and intracellular peptide/protein delivery for proteome restoration therapy. Since its prior renewal in 2006, these conceptual and cutting edge technological resources have provided tremendous opportunities for enhanced hands-on research experience and career development to 14 predoctoral and 19 postdoctoral trainees, including those from underrepresented groups. The Program's flagship course "Functional Genomics and Proteomics: Applications to Immunobiology" provides the unifying didactic platform. The institutional course on Responsible Conduct of Research is complemented by the Program-specific discussion groups. By requesting 5 predoctoral and 5 postdoctoral trainee slots, we respond to a growing demand for training from the Academic Community. The IBVSTP Steering Committee applies stringent admission criteria for selection of training candidates, including emphasis on translational goals of proposed projects, and evaluates trainees' performance. Postdoctoral trainees with Ph.D. and/or M.D. degrees are appointed following review by the IBVSTP Steering Committee and are advised by mentoring teams that represent the Program's Affinity Groups. The input of External Advisors and Consultants and a continuing feedback from trainees provide additional training quality checkpoints that enhance the Program's strong record of preparing the next generation of investigators in fundamental, translational, and clinical research focused on inflammation as the major mechanism of diseases affecting blood and vascular systems.