Integrating innate and adaptive pathways in vaccine responses

描述（由申请人提供）：该项目的目标是对人类持久、保护性免疫反应的演变进行定向研究，以便更好地了解有效疫苗和佐剂的要求。本申请是为了获得洛克菲勒大学人类免疫学合作中心的资助而提交的。我们的项目是高度整合的，基于pi之间在定义人类免疫学基本原则方面的长期、富有成效的合作，利用洛克菲勒大学医院、Zanvil Cohn疫苗中心和洛克菲勒大学临床和转化科学奖（CTSA）的基础设施。拟议的研究项目被设计为假设检验、机制研究，在传染病疫苗接种的背景下研究人类免疫反应的激活和调节的新方面。参与调查的人员是鉴定的先驱

DESCRIPTION (provided by applicant): The goal of this program is to perform directed investigations into the evolution of lasting, protective Immune responses in humans in order to better understand the requirements of effective vaccines and adjuvants. This application is submitted to obtain funding for a Cooperative Center on Human Immunology at The Rockefeller University. Our program is highly integrated and is based on long-term, productive collaborations between the PIs on defining underlying principles of human immunology, utilizing the infrastructure of the Rockefeller University Hospital, the Zanvil Cohn Vaccine Center and the Rockefeller University Clinical and Translational Science Award (CTSA). The proposed research projects are designed as hypothesis-testing, mechanistic studies, examining novel aspects of the activation and regulation of human immune responses in the context of vaccination against infectious disease. The participating investigators are pioneers in identifying and characterizing basic mechanisms of the human immune response, having contributed to the initial characterizations of the dendritic cell, the diversity of IgG antibody effector functions ad description of Fc receptors as mediators of immunity, the development of the first models for study of the hepatitis C virus and the Identification of multiple HCV receptors. While significant progress in basic immunology research over the last three decades has resulted in numerous medical advances, a much more substantial understanding of coordinated molecular mechanisms involved in eliciting Immunity will be required to enable judicious vaccine design, particularly for diseases for which no vaccines currently exits. The objective of this proposal is o draw on the broad expertise in immunity and infectious diseases within the collaborating laboratories to define the contributions of critical components, such as dendritic cells, T follicuar helper cells, monocytes and immune complexes in the generation and maintenance of effective immune responses to infectious agents.