Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-Old

项目-2概要/摘要： 阿尔茨海默病（AD）的患病率与阿尔茨海默病（AD）的存在密切相关。 心血管疾病（CaVD），了解AD病理和CaVD之间的关系至关重要 重要.在本计划项目（PPG 3）的竞争性更新中，我们将探讨我们的发现是否 与CaVD和Aβ病理学相关的研究将适用于更多样化的队列。总体 PPG 3项目2的目标是进一步了解AD病理学与中年之间的关系 青年老年人CaVD及其对认知功能损害的影响为了实现这些目标， 我们将利用一组来自现有队列的非痴呆参与者，这些队列来自正在进行的基于社区的 心脏战略集中于风险评估（心脏评分）研究，一项纵向研究，开始于 2003年，研究时年龄在45-75岁之间的2000名参与者（43%为非洲裔美国人）队列 并收集了大量的纵向血管测量数据。本研究将探讨两个主要的 假说探讨了两种假说：1）CaVD和淀粉样蛋白β（Aβ）沉积是 认知能力下降，CaVD增加通过干扰血管相关的 2）CaVD加速Aβ在脑内的沉积，从而加速脑梗死的发生。 临床症状。这项研究的结果将有助于我们进一步了解 血管病理与中年AD病理的关系。

Project-2 Summary/Abstract: The prevalence of Alzheimer's disease (AD) is closely related to the presence of cardiovascular disease (CaVD), understanding the relationship between AD pathology and CaVD is critically important. In the competing renewal of this Program Project (PPG3), we will explore whether our finding related to CaVD and Aβ pathology in a very elderly cohort will apply to a more diverse cohort. The overarching goal of Project 2 of PPG3 is to further the understanding of the relationship between AD pathology and midlife CaVD and the impact of these factors on cognitive impairment in a group of young old. To achieve these goals, we will utilize a group non-demented participants from an existing cohort from the ongoing community-based Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a longitudinal study that began in 2003 with a cohort of 2000 participants (43% African American) between the ages of 45-75 years at study entry and has collected a wealth of longitudinal vascular measures. This study will explore two main hypotheses explore two hypotheses: 1) CaVD and amyloid-beta (Aβ) deposition are independent predictors of cognitive decline, and increased CaVD creates a state of vulnerability by interfering with vascular-related compensatory mechanisms; and 2) CaVD accelerates Aβ deposition in the brain, thus accelerating the onset of clinical symptoms. The findings from this study will help to further inform our understanding of the relationship between vascular pathology and AD pathology in midlife.