Long noncoding RNAs in alcoholic liver disease

 描述(申请人提供)：酒精性肝病(ALD)是主要的公共卫生问题。在西方世界，它是慢性肝病的主要病因，具有显著的发病率/死亡率和经济负担。有趣的是，它只发生在高达20%-30%的过度饮酒者中，这表明在一部分受试者中，除了酒精之外，可能还有其他因素参与了从过度饮酒到ALD的过程。人类转录组的新格局以及非编码RNA(NcRNAs)的识别揭示了它们在人类疾病病理生理学中的重要性。然而，lncRNA在ALD中的作用仍是完全未知和未被探索的。这一探索性的R21应用将通过揭示lncRNAs在ALD的发病和进展中的作用来填补这一知识空白。

 DESCRIPTION (provided by applicant): Alcoholic liver disease (ALD) is the major public health problem. It is the leading cause of chronic liver disease with significant morbidity/mortaliy and economic burdens in the western world. Interestingly, it only occurs in up to 20%-30% of excessive drinkers, suggesting that other factors in addition to alcohol might be involved in the progression from excessive drinking to ALD in a subset of subjects. The new landscape of human transcriptome along with the identification of noncoding RNAs (ncRNAs) has uncovered their importance in the pathophysiology of human diseases. However, the function of lncRNA in ALD remains completely unknown and unexplored. This exploratory R21 application will fill in this knowledge gap by reveling the roles of lncRNAs in the pathogenesis and progression of ALD.