Core B: Animal Models and Pathology

摘要 建立动物模型和病理学核心，提供必要的动物和病理资源 全面支持利用动物模型的研究项目的组件。这样做的具体目的是 核心是：具体目标1-维持各种小鼠品系的质量受控繁育群体；具体 目标2-开发新的转基因小鼠品系并保持繁殖的小鼠群体 专门用于该计划中的个别项目；具体目标3--产生小鼠胚胎 个别项目中提出的来自不同小鼠品系的成纤维细胞(MEF)；具体目标4-提供动物 为体内癌症模型提供病理学服务；以及特定目标5-为肿瘤组织染色提供服务 以及IHC和TMA的表征。

SUMMARY The Animal Models and Pathology Core is established to provide essential animal and pathology resource components that comprehensively support research Projects utilizing animal models. The Specific Aims of this Core are: Specific Aim 1 - To maintain quality controlled breeding colonies for various mouse strains; Specific Aim 2 - To develop novel strains of transgenic mice and maintain breeding colonies of mice that will be specifically utilized by individual Projects in the Program; Specific Aim 3 - To generate mouse embryonic fibroblasts (MEFs) from various mice strains proposed in individual projects; Specific Aim 4 - To provide animal pathology services for in vivo cancer models; and Specific Aim 5 - To provide services for tumor tissue staining and characterization by IHC and TMA.