Sensitivity enhancement of MRI with a Wireless Amplified NMR Detector

摘要：钱春琪博士正在申请K99/R00职业生涯过渡奖，为 他的直接职业目标是成为一家学术机构的独立教员。 钱博士的长期职业目标是为下一代开发先进的检测技术 生成具有更高灵敏度和准确性的MRI诊断。为了实现这一目标，钱博士 在磁共振研究领域连续工作多年。他的博士学位 著名的专业期刊《磁学杂志》强调了论文工作 共振，因为他在建筑中新颖地实现了无线耦合技术 一个可变角度的磁共振探测器。在他在国家高磁研究所做博士后研究期间 野外实验室，钱博士成功地构建了一个具有良好性能的大范围可调探测器 世界上最高的21.1特斯拉磁场磁共振成像的均匀性和效率。这一点很重要 因此，进展使得用于生物医学成像的高场磁体的实际开发成为可能。 这项工作还获得了国际青年研究者奖 磁共振显微镜会议。作为美国国立卫生研究院的研究员，钱博士为 第一次开发了一种非常有前景的技术，可以极大地增强MRI检测 内脏敏感度，基于无线放大的创新设计理念 侦测。这项新技术已经被应用于获得高分辨率的图像 啮齿动物的活体肾脏，使得能够检测到单个肾小球和肾小管。为了进一步 提高成像分辨率，钱博士将通过动态跟踪来减少运动伪影 如目标1所述，物体随着植入的探测器本身运动。为了最大化 图像对比度，钱博士将使用不同的造影剂来可视化不同的成分 并将这些高分辨率图像与组织学研究相关联，如 目标2.这两个具体目标将在艾伦·科雷茨基博士的指导下实现， 在此期间，钱博士将得到NINDS的全力支持。在钱博士获得 作为一名独立的教职员工，他将继续开发无线放大器 并开发其生物医学应用。正如在目标3中总结的那样，钱博士将 利用微细加工技术制作小型化无线放大探测器。按原样 简而言之，钱博士将在目标4中构建阵列无线探测器，以获得更大的 视场，其中每个探测器可以由特定的泵浦信号单独操纵。 预计无线放大器技术的进一步发展将导致这样的结果 在工程组织慢性监测和原位化学传感方面的应用 在消化轨道内。

Abstract: Dr. Chunqi Qian is applying for the K99/R00 career transition award in preparation for his immediate career goal to become an independent faculty member in an academic institution. Dr. Qian's long term career goal is to develop advanced detection technologies for the next generation MRI diagnosis with better sensitivity and accuracy. To achieve this goal, Dr. Qian has been continuously working in the research field of magnetic resonance for many years. His PhD thesis work was highlighted by the prestigious professional journal, the Journal of Magnetic Resonance, for his novel implementation of the wireless coupling technique in the construction of a variable angle MR detector. During his postdoctoral research at the National High Magnetic Field Laboratory, Dr. Qian successfully constructed a broad range tunable detector with good homogeneity and efficiency for the world's highest field MRI at 21.1 Tesla. This important progress has thus enabled the practical exploitation of high field magnet for biomedical imaging. This work has also been honored by the Young Investigator Award during the International Conference in Magnetic Resonance Microscopy. As a research fellow at NIH, Dr. Qian has for the first time developed a very promising technology that can greatly enhance the MRI detection sensitivity of internal organs, based on the innovative design concept of wireless amplified detection. This new technology has already been applied to obtain high resolution images of rodent kidney in vivo, enabling the detection of individual glomeruli and renal tubules. To further improve the imaging resolution, Dr. Qian will reduce the motional artifact by dynamically tracking the object motion with implanted detector itself, as is mentioned in Aim 1. To maximize the image contrast, Dr. Qian will use different contrast agents to visualize different components of nephron and correlate these high resolution images with histological studies, as is mentioned in Aim 2. These two specific aims will be accomplished under the mentorship of Dr. Alan Koretsky, during which time Dr. Qian will receive complete support from the NINDS. After Dr. Qian obtains an independent faculty position, he will continue the development of the wireless amplifier technology and exploit its biomedical applications. As is summarized in Aim 3, Dr. Qian will fabricate miniaturized wireless amplified detectors with microfabrication techniques. As is summarized in Aim 4, Dr. Qian will construct arrayed wireless detectors to get a bigger field-of-view, where each detector can be individually manipulated by a specific pumping signal. It is anticipated that further development of the wireless amplifier technology will lead to such applications as the chronic monitoring of engineered tissues and the in situ chemical sensing inside the digestive track.