Numerical Investigation of anatomical structure and material property of vocal fold on phonation

 描述（由申请人提供）：根据其力学特性，人类声带可分为三层：粘膜加固有层浅层（Reinke间隙）、韧带和肌肉。这些层的几何形状和材料特性决定了声带的振动特性。尽管人们早已认识到声带多层结构的重要性，但对声带各层几何结构和材料特性的变化如何影响发声的理解仍然非常有限。改进此种 了解这一点将有利于嗓音治疗和临床研究。例如，它可以让我们预测/估计组织损伤的影响，即表层的硬化 以及注入生物材料的位置。它也有助于工程化声带组织和替代受损组织的假体的开发。了解发声对什么样的几何形状和材料属性最敏感，对于未来的模型创建或模型复杂性降低也是有价值的。PI建议利用高性能，三维连续介质力学为基础的流动-结构相互作用模型，系统地检查和量化的几何形状和材料特性的声带层发声的影响。该研究旨在确定发声最敏感的声带层的几何形状和材料特性，并了解这些特性的变化如何影响声带振动和声音。长期目标是建立一个直接的 声带解剖（几何形状和材料特性）和发声之间的因果关系。研究的两个具体目标是：（1）研究声带层的几何形状对振动动力学、空气动力学和声源的影响;（2）研究声带层的材料特性对振动动力学、空气动力学和声源的影响。

 DESCRIPTION (provided by applicant): Based on its mechanical properties, human vocal fold can be divided into three layers: mucosa plus superficial layer of lamina propria (Reinke's space), ligament, and muscle. The geometry and material properties of these layers determine vocal fold vibratory characteristics. Although the importance of the multilayered structure of vocal fold has long been recognized, the understanding of how the variations of the geometry and material properties of vocal fold layers affect phonation is still very limited. Improving such understanding would benefit both voice treatment and clinical research. For example, it could allow us to predict/estimate the impact of tissue damage, i.e. stiffening of the superficial layers of the vocal fold, and the placement of injected biomaterials. It could also assist the development of engineering vocal fold tissue and prosthesis for replacing damaged tissue. Knowing what geometry and material properties that phonation is most sensitive to could also be valuable for future model creation or model complexity reduction. The PIs propose to utilize a high performance, three-dimensional continuum mechanics based flow-structure interaction model to systematically examine and quantify the effects of geometry and material properties of vocal fold layers on phonation. The study aims to identify the geometry and material properties of vocal fold layers that phonation is most sensitive to, and understand how the variations of these properties affect vocal fold vibration and voice. The long term goal is to establish a direct cause-effect link between vocal fold anatomy (geometry and material properties) and phonation. The two specific aims are as follows: (1) investigate the effects of geometry of vocal fold layers on vibratory dynamics, aerodynamics and sound sources; (2) investigate the effects of material properties of vocal fold layers on vibratory dynamics, aerodynamics and sound sources.