Intervention and Implementation Science Core

项目总结 由于生物医学的引入，艾滋病毒预防科学正处于一个显著的发展时期。 预防模式，以补充传统的行为战略。新的战略已经创造了 艾滋病毒预防和治疗成果之间的协同增效作用，其基础是认识到现在存在 一套工具，如果组合得当，可以阻止疫情的传播并有效地治疗 绝大多数艾滋病毒携带者。最近的政策倡议将重点放在缩小差距上 在预防和护理方面，以及将干预措施转化为有效做法方面。我们提议增加一名 新的干预和实施科学(I&I)核心，推动艾滋病毒预防的科学进步 通过整合艾滋病毒干预科学的各个领域的研究，包括基础研究、疗效 试验和实施研究。I&I核心将以以下目标为指导：(1)激励 艾滋病毒干预科学领域的跨学科进展，通过利用最新的 在基础和艾滋病毒相关的生物医学、社会/行为、心理健康、公共健康和技术方面的研究结果- 相关学术学科，为艾滋病毒干预设计、测试和扩大的创新提供信息； 确定临床、社会和行为干预之间的互补性和协同性领域 支持强化组合和生物行为艾滋病毒预防方法的战略；并通过促进 多学科科学家合作进行创新干预研究并指导 将有效的干预措施转化为实践。(2)在CAPS及其附属公司中磨练技能 科学家沿着艾滋病毒干预和实施科学的光谱工作，通过 增加有关常规和前沿干预措施开发和实施的知识 具有文化能力的方法，可用于解决无数预防目标，来自 采用和坚持生物医学进步的行为、结构和社会变化； 在不同的组织、政治和社会结构中培养学习和工作的流畅性，以促进 将有效的干预措施转化为实践。(3)确保CAPS研究，包括干预和 实施研究，达到最高道德标准，通过提供道德咨询来实现 和研究项目中出现的人类主题问题；提高对伦理和人类的认识 在这个更多地使用技术的时代主题问题；并在形成数据和提供援助方面提供帮助 安全监测委员会。

PROJECT SUMMARY HIV prevention science is in a period of marked evolution, prompted by the introduction of biomedical prevention modalities to complement traditional behavioral strategies. The new strategies have created synergies between HIV prevention and treatment outcomes, based on the recognition that there now exists a set of tools that, if utilized in the right combination, could stop the spread of the epidemic and effectively treat the vast majority of individuals living with HIV. Recent policy initiatives place a critical focus on closing the gaps in prevention and care, and on translating interventions into effective practice. We are proposing the addition of the new Intervention and Implementation Science (I&I) Core, to drive the scientific evolution in HIV prevention by integrating research across the spectrum of HIV intervention science, including basic research, efficacy trials, and implementation research. The I&I Core will be guided by the following aims: (1) To galvanize interdisciplinary advances across the spectrum of HIV intervention science, achieved by leveraging the latest findings in basic and HIV-related biomedical, social/behavioral, mental health, public health, and technology- related academic disciplines to inform innovations in HIV intervention design, testing, and scale-up; by identifying areas of complementariness and synergy among clinical, social, and behavioral intervention strategies to support enhanced combination and bio-behavioral HIV prevention approaches; and by fostering collaboration among multidisciplinary scientists to conduct innovative intervention research and guide the translation of effective interventions into practice. (2) To hone the skills among CAPS and its affiliated scientists for working along the spectrum of HIV intervention and implementation science, achieved by increasing knowledge about conventional and cutting-edge intervention development and implementation approaches that are culturally competent, and can be used to address myriad prevention targets, from behavioral, structural, and social change to adoption of and adherence to biomedical advances; and by developing fluency to study and work within diverse organizational, political, and social structures to foster the translation of effective interventions into practice. (3) To assure that CAPS research, including intervention and implementation research, meets the highest ethical standards, achieved by providing consultations on ethical and human subjects issues arising in research projects; increasing awareness about ethical and human subjects issues in this era of greater use of technology; and providing assistance in the formation of Data and Safety Monitoring Boards.