Pharmacological strategies to enhance endogenous opioid actions in pain circuits.

增强我们大脑中的内源性阿片类药物作用可能使我们能够利用这个系统来减少疼痛和相关的残疾，而不会出现与阿片类药物相关的成瘾和过量威胁。我们已经表明，我们可以使用两种药理学策略增强内源性阿片类药物的作用。我们现在将确定如何使用这些策略来增强内源性阿片类药物对疼痛和相关焦虑症中重要的神经功能和行为的调节。

Boosting endogenous opioid actions in our brain may allow us to utilize this system to reduce pain and the related disability without the addiction and overdose threat associated with opioid drugs. We have shown that we can enhance endogenous opioid actions using two pharmacological strategies. We will now determine how we can use these strategies to enhance endogenous opioid regulation of the neural function and behaviours important in pain and related anxiety disorders.