Placental malaria, placental function, nutrient transport and fetal growth restriction

胎盘中的疟疾感染可能通过引起胎盘炎症而损害婴儿的生长。我们认为这种炎症干扰了胎盘细胞将营养物质如氨基酸和葡萄糖从母亲输送给婴儿的能力。我们将通过检测孕妇胎盘样本和细胞系中参与营养转运的基因和蛋白质的表达来测试这一点，并将研究疟疾如何影响控制这一过程的生长因子。

Malaria infection in the placenta impairs the baby's growth, probably by causing placental inflammation. We believe this inflammation interferes with the ability of placental cells to transport nutrients such as amino acids and glucose from mother to baby. We will test this by examining the expression of genes and proteins involved in nutrient transport in placental samples from pregnant women, and in cell lines, and will examine how malaria affects growth factors that control this process.