Plasmodium knowlesi as a genetic model for Plasmodium vivax drug resistance

两种不同的疟原虫导致了世界上大多数疟疾。然而，有一种类型的间日疟原虫不能在实验室中培养，因此对它的研究很少。已经观察到了耐药性，但其根本原因却知之甚少。我们建议使用一种密切相关的寄生虫诺氏假单胞菌作为了解耐药机制的模型。这些知识将被用来跟踪现场的耐药性，并指导最适当的治疗政策。

Two different Plasmodium parasites cause the majority of malaria worldwide. However, one type, P. vivax, is unable to be cultured in the laboratory and therefore has been poorly studied. Drug resistance has been observed but the underlying causes are poorly understood. We propose to use a closely related parasite, P. knowlesi, as a model to understand drug resistance mechanisms. This knowledge will be used to follow resistance in the field and direct policy of the most appropriate treatment.