Polyunsaturated fat as a protective agent in the dietary management of early overweight

这项研究大大增加了我们对饮食结构对体重管理的影响的了解。它建立在动物模型研究的基础上，展示了不同类型的脂肪对肥胖发展的影响，以及我们对糖尿病患者的研究，在这些研究中，我们发现低脂肪饮食中多不饱和脂肪的比例越高，身体脂肪损失就越大。我们提议的研究将证明，同样的饮食结构是否可以减少超重但不患有糖尿病的人的内脏脂肪，以及我们是否需要减少卡路里来实现这一目标。这可能是由于用作燃料的脂肪水平较高、代谢率较高或食欲下降所致。我们将能够确定这些影响，并添加到饮食成分和能量平衡的科学知识库中。如果我们要制定比一般的饮食健康声明更具体、更有效的体重管理饮食建议，掌握这些知识是很重要的。这项研究的最大优势之一是食物指导系统得到了充分的发展。我们不仅将证明饮食的营养成分达到了目标，食物指南系统还为人们提供了在自由生活条件下选择食物的机会。因此，与这项研究和临床实践模式的联系将得到保证。然后，这项研究的影响可能会通过更有效的临床策略来评估，以管理肥胖，这是一个主要的公共卫生问题。

This study adds significantly to our knowledge of the effect of diet composition on weight management. It builds on animal model studies demonstrating the effects of different types of fat on obesity development, and on our research in people with diabetes, where we found a higher proportion of polyunsaturated fats in a low fat diet resulted in greater body fat loss. Our proposed research will demonstrate whether this same dietary profile can reduce visceral fat in people who are overweight but not diabetic, and whether we need to reduce calories or not to achieve this end. It may be that the effect is due to a higher level of fat used as fuel, a higher metabolic rate, or a reduction in appetite. We will be able to determine these effects, and add to the scientific knowledge base of dietary components and energy balance. Having this knowledge is important if we are to develop dietary advice for weight management that is more specific and effective than general statements on eating well. One of the great strengths of this study is that the food guidance system is fully developed. Not only will we will prove the targeted nutrient composition of the diet is achieved, the food guidance system provides for people to chose foods under free living conditions. Thus the link to this research and clinical practice models will be assured. The impact of this research may then be assessed in terms of more effective clinical strategies for the management of obesity, a major public health concern.