Predicting, diagnosing and treating synucleinopathies

帕金森氏病和路易体痴呆症带来了很高的社会经济负担，目前还没有改善疾病的治疗方法。现有的对症治疗侧重于替换神经递质，这些神经递质是由在临床诊断之前大多已退化的神经元产生的，因此显然有必要在可能从神经保护干预中受益最大的阶段识别病例，以及改进对症和开发疾病修改治疗。

Parkinson’s Disease and Lewy Body Dementia carry a high socioeconomic burden and there are currently no disease-modifying treatments. Existing symptomatic therapies focus on replacing neurotransmitters that are made by neurons that have mostly degenerated prior to clinical diagnosis, warranting a clear need to identify cases at a stage when they might benefit most from neuroprotective interventions, as well as improving symptomatic and developing disease modifying treatments.