MOLECULAR APPROACHES TO OVERCOME SCABIES AND ASSOCIATED DISEASE

麻疹会导致儿童脓皮病，在以后的生活中容易患上严重的疾病。这是北澳大利亚土著人民日益严重的健康负担。在蠕虫和细菌中，抗药性正在形成。临床资料的缺乏阻碍了分子研究，这项工作将利用寄生和自由生活的螨类的比较基因组学和微生物组分析来了解螨类生物学和发病的基本方面。了解对螨虫生存和干扰宿主防御至关重要的蛋白质，将使多肽抑制剂的知情设计成为开发替代治疗方案的新策略。

Scabies causes childhood pyoderma predisposing to severe disease in later life. It is a major increasing health burden in Indigenous people of Northern Australia. Drug resistance is developing in mites and bacteria. The lack of clinical material has hampered molecular research and this work will use comparative genomics of parasitic and free living mites and microbiome analysis to understand fundamental aspects of mite biology and pathogenesis. The understanding of proteins that are essential for mite survival and interfere with host defences will allow the informed design of peptide inhibitors as a new strategy to develop alternative treatment options.