Preventing inflammation-induced brain injury in preterm infants: targeting systemic tumour necrosis factor

脑瘫是一种致命的终身疾病。很大一部分病例与早产时暴露于炎症有关。没有有效的治疗方法。我们的研究将研究炎症如何损害早产儿的大脑发育和功能，并测试阻断血液中一种称为肿瘤坏死因子的关键炎症蛋白是否能改善大脑发育。我们将产生减少早产儿残疾的关键知识。

Cerebral palsy is a devastating life-long condition. A large proportion of cases are associated with exposure to inflammation at the time of preterm birth. There is no effective treatment. Our studies will examine how inflammation impairs brain development and function in preterm infants and test whether blocking a key inflammatory protein in the blood, called tumour necrosis factor, improves brain development. We will generate critical knowledge towards reducing disability in preterm infants.