Protecting the Gut: A Novel Therapeutic Avenue for Reducing the Damaging Consequences of Obesity

大多数肥胖症患者都会出现肠道功能障碍。包括便秘和腹泻在内的症状通常出现在糖尿病和心脏病等其他常见并存疾病之前，这表明肥胖症的早期病理可能始于肠道。这项研究项目旨在了解肥胖小鼠和人类患者肠道功能障碍的机制，并测试一种临床批准的化合物，该化合物首次在肥胖症中显示出肠道保护特性。

Most patients with obesity develop gut dysfunction. Symptoms including constipation and diarrhoea often present before other common comorbidities like diabetes and heart disease, suggesting that early pathology in obesity may begin in the gut. This research project aims to understand the mechanisms through which gut dysfunction develops in obese mice and human patients, and test a clinically approved compound that has demonstrated gut protective properties for the first time in obesity.